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1. (WO2009136162) INTERMEDIATE AND PROCESSES INVOLVED IN THE PREPARATION OF 2 ' -CYANO-2 ' -DE0XY-N4-PALMIT0YL-1-BETA-ARABIN0FURAN0SYLCYTOSINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/136162    International Application No.:    PCT/GB2009/001141
Publication Date: 12.11.2009 International Filing Date: 08.05.2009
IPC:
A61K 31/7068 (2006.01), C07F 7/08 (2006.01), C07H 19/06 (2006.01), A61P 35/00 (2006.01)
Applicants: CYCLACEL LIMITED [GB/GB]; 6-8 Underwood Street London N1 7JQ (GB) (For All Designated States Except US).
WOOD, Gavin, Jeffrey [GB/GB]; (GB) (For US Only).
WESTWOOD, Robert [GB/GB]; (GB) (For US Only)
Inventors: WOOD, Gavin, Jeffrey; (GB).
WESTWOOD, Robert; (GB)
Agent: CLYDE-WATSON, Zoe; D Young & Co LLP 120 Holborn London EC1N 2DY (GB)
Priority Data:
0808359.4 08.05.2008 GB
Title (EN) INTERMEDIATE AND PROCESSES INVOLVED IN THE PREPARATION OF 2 ' -CYANO-2 ' -DE0XY-N4-PALMIT0YL-1-BETA-ARABIN0FURAN0SYLCYTOSINE
(FR) INTERMÉDIAIRE ET PROCÉDÉS ASSOCIÉS À LA PRÉPARATION DE 2'-CYANO-2'-DÉSOXY-N4-PALMITOYL-1-BÊTA-ARABINOFURANOSYLCYTOSINE
Abstract: front page image
(EN)The present invention relates to a process for preparing a compound of formula (682-6'), said process comprising the steps of: formula (682-4), (682-5), (682-6'): (i) converting a compound of formula (682-4) into a compound of formula (682-5); and (ii) converting said compound of formula (682-5) into a compound of formula (682- 6'). Further aspects of the invention relate to the use of the above process in the preparation of 2'-cyano-2'-deoxy-N4-palmitoyl-l-β-D-arabinofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.
(FR)La présente invention concerne un procédé pour préparer un composé de formule 682-6', ledit procédé comprenant les étapes de formule (682-4, 682-5, 682-6') : (i) conversion d’un composé de formule 682-4 en composé de formule 682-5; et (ii) conversion dudit composé de formule 682-5 en composé de formule 682-6'. D’autres aspects de l’invention concernent l’utilisation du procédé ci-dessus dans la préparation de la 2'-cyano-2'-désoxy-N4-palmitoyl-1-β-D-arabinofuranosylcytosine, un nucléoside pyrimidinique qui est thérapeutiquement utile dans le traitement et/ou la prévention du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)