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1. (WO2009136158) PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHEIS OF 2'-CYANO-2'-DEOXY-N4-PALMITOYL-1-BETA-D-ARABINOFURANOSYLCYTOSINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/136158    International Application No.:    PCT/GB2009/001134
Publication Date: 12.11.2009 International Filing Date: 08.05.2009
IPC:
A61K 31/7068 (2006.01), C07F 7/08 (2006.01), C07H 19/06 (2006.01), A61P 35/00 (2006.01)
Applicants: CYCLACEL LIMITED [GB/GB]; 6-8 Underwood Street London N1 7JQ (GB) (For All Designated States Except US).
WOOD, Gavin, Jeffrey [GB/GB]; (GB) (For US Only).
WESTWOOD, Robert [GB/GB]; (GB) (For US Only)
Inventors: WOOD, Gavin, Jeffrey; (GB).
WESTWOOD, Robert; (GB)
Agent: CLYDE-WATSON, Zoe; D Young & Co LLP 120 Holborn London EC1N 2DY (GB)
Priority Data:
0808357.8 08.05.2008 GB
Title (EN) PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHEIS OF 2'-CYANO-2'-DEOXY-N4-PALMITOYL-1-BETA-D-ARABINOFURANOSYLCYTOSINE
(FR) PRÉPARATION D'INTERMÉDIAIRES UTILES DANS LA SYNTHÈSE DE 2'-CYANO-2'-DÉSOXY-N4-PALMITOYL-1-BETA-D-ARABINOFURANOSYLCYTOSINE
Abstract: front page image
(EN)The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of: (i) converting a compound of formula 682-1 into a compound of formula 682-2'; (ii) converting said compound of formula 682-2' into a compound of formula 682-3; and (iii) converting said compound of formula 682-3 into a compound of formula 682-4. Further aspects of the invention relate to the use of the above process in the preparation of 2'-cyano-2'-deoxy-N4 -palmitoyl-1-β-D-arabmofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.
(FR)La présente invention porte sur un procédé de préparation d'un composé de formule (682-4). Ce procédé comprend les étapes consistant à : (i) convertir un composé de formule (682-1) en un composé de formule (682-2'); (ii) convertir ledit composé de formule (682-2') en un composé de formule (682-3); et (iii) convertir ledit composé de formule (682-3) en un composé de formule (682-4). D'autres aspects de l'invention portent sur l'utilisation du procédé ci-dessus dans la préparation de la 2'-cyano-2'-désoxy-N4-palmitoyl-1-β-D-arabinofuranosylcytosine, un nucléoside pyrimidique qui est thérapeutiquement utile dans le traitement et/ou la prévention du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)