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Machine translation
1. (WO2009136007) PEPTIDE HOMING TO BRAIN TUMORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/136007    International Application No.:    PCT/FI2009/050375
Publication Date: 12.11.2009 International Filing Date: 08.05.2009
IPC:
C07K 7/06 (2006.01), A61K 38/08 (2006.01), A61P 35/00 (2006.01)
Applicants: LAAKKONEN, Pirjo [FI/FI]; (FI).
BURNHAM INSTITUTE FOR MEDICAL RESEARCH [US/US]; 10901 North Torrey Pines Road La Jolla, California 92037 (US) (For All Designated States Except US).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF CALIFORNIA SAN FRANCISCO ("UCSF") [US/US]; 185 Berry Street, Suite 4603 San Francisco, California 94107 (US) (For All Designated States Except US).
RUOSLAHTI, Erkki [FI/US]; (US) (For US Only).
BERGERS, Gabriele [US/US]; (US) (For US Only)
Inventors: LAAKKONEN, Pirjo; (FI).
RUOSLAHTI, Erkki; (US).
BERGERS, Gabriele; (US)
Agent: OY JALO ANT-WUORINEN AB; Iso Roobertinkatu 4-6 A FI-00120 Helsinki (FI)
Priority Data:
20085427 09.05.2008 FI
61/071,644 09.05.2008 US
Title (EN) PEPTIDE HOMING TO BRAIN TUMORS
(FR) PEPTIDE MIGRANT VERS LES TUMEURS DU CERVEAU
Abstract: front page image
(EN)The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.
(FR)L'invention porte sur un peptide qui migre spécifiquement vers le modèle intracrânien du stade précoce d'astrocytome qui se développe dans le cerveau sous la forme d'îlots renfermant des vaisseaux tumoraux. Ledit peptide trouve son utilisation dans l'administration ciblée de substances thérapeutiques à des cancers du cerveau invasifs ou à des lésions cérébrales métastatiques, seul ou en association avec des thérapies conventionnelles, telles que la chirurgie et la radiothérapie et des thérapies antiangiogéniques, et comme outil diagnostique, par exemple pour le cancer du cerveau invasif ou les lésions cérébrales métastatiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)