WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009135944) TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/135944    International Application No.:    PCT/EP2009/055617
Publication Date: 12.11.2009 International Filing Date: 08.05.2009
IPC:
C07D 231/38 (2006.01), C07D 401/04 (2006.01), C07D 407/04 (2006.01), C07D 407/14 (2006.01), A61K 31/455 (2006.01), A61P 25/00 (2006.01)
Applicants: JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse (BE) (For All Designated States Except US).
THURING, Johannes Wilhelmus John F. [NL/BE]; (BE) (For US Only).
MACDONALD, Gregor, James [GB/BE]; (BE) (For US Only).
ZHUANG, Wei [CN/BE]; (BE) (For US Only)
Inventors: THURING, Johannes Wilhelmus John F.; (BE).
MACDONALD, Gregor, James; (BE).
ZHUANG, Wei; (BE)
Common
Representative:
JANSSEN PHARMACEUTICA NV; Turnhoutseweg 30 B-2340 Beerse (BE)
Priority Data:
08155991.6 09.05.2008 EP
Title (EN) TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS
(FR) PYRAZOLES TRISUBSTITUÉS EN TANT QUE MODULATEURS DES RÉCEPTEURS DE L'ACÉTYLCHOLINE
Abstract: front page image
(EN)The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
(FR)La présente invention concerne des dérivés 1-alkyl-3-anilino-5-aryl-pyrazoles et leurs sels pharmaceutiquement acceptables, des procédés pour les préparer, des compositions pharmaceutiques les contenant, et leur utilisation en thérapeutique, ces dérivés étant représentés par la formule (I). L'invention concerne en particulier des modulateurs allostériques positifs des récepteurs nicotiniques de l'acétylcholine, ces modulateurs allostériques positifs ayant la capacité d'augmenter l'efficacité des agonistes des récepteurs nicotiniques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)