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1. WO2009135885 - FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

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Publication Number WO/2009/135885
Publication Date 12.11.2009
International Application No. PCT/EP2009/055500
International Filing Date 06.05.2009
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4995
Pyrazines or piperazines forming part of bridged ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
C07D 519/00 (2006.01)
A61K 31/4985 (2006.01)
A61K 31/4995 (2006.01)
A61P 19/02 (2006.01)
CPC
C07D 519/00
Applicants
  • GALAPAGOS NV [BE/BE]; Generaal De Wittelaan L11 A3 B-2800 Mechelen, BE (AllExceptUS)
  • ANDREWS, Martin James Inglis [GB/BE]; BE (UsOnly)
  • CHAMBERS, Mark Stuart [GB/GB]; GB (UsOnly)
  • VAN DE POËL, Hervé [FR/GB]; GB (UsOnly)
  • BAR, Grégory Louis Joseph [FR/BE]; BE (UsOnly)
Inventors
  • ANDREWS, Martin James Inglis; BE
  • CHAMBERS, Mark Stuart; GB
  • VAN DE POËL, Hervé; GB
  • BAR, Grégory Louis Joseph; BE
Agents
  • NICHOL, Maria; Galapagos NV Chesterford Research Park Saffron Walden Essex CB10 1XL, GB
Priority Data
61/126,83307.05.2008US
61/145,82720.01.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
(FR) COMPOSÉS DE PYRAZINE FUSIONNÉE UTILES DANS LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
front page image
Abstract
(EN)
Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: Formula (Ia) or Formula (Ib). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, pain, inflammation, and others.
(FR)
La présente invention concerne de nouveaux composés de [1.2.4]triazolo[1,5-a]pyrazine et d’imidazo[1,2-a]pyrazine de formule (Ia) ou de formule (Ib). Lesdits composés peuvent être préparés en tant que compositions pharmaceutiques, et peuvent être utilisés dans la prévention et le traitement d’une variété de maladies chez les mammifères (notamment les humains), y compris – sans s’y limiter – la douleur, l’inflammation et d’autres troubles.
Also published as
AU2009245731
BRPI0912412
CA2723745
CN102036997
CO10152830
CR201011823
CRCR2010-011823
EA201071275
EG2010111865
EP2307426
ID051.1467
IL209104
IN8591/DELNP/2010
JP2011519897
KR1020110028445
MXMX/a/2010/011994
NZ589665
PH12010502487
SG165947
UAa201014667
VN1201003287
VN26462
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