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1. (WO2009135788) HETEROCYCLIC ANTIVIRAL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/135788    International Application No.:    PCT/EP2009/055164
Publication Date: 12.11.2009 International Filing Date: 29.04.2009
IPC:
C07D 471/10 (2006.01), A61K 31/4545 (2006.01), A61P 31/18 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
ROTSTEIN, David Mark [US/US]; (US) (For US Only).
YANG, Hanbiao [CN/US]; (US) (For US Only)
Inventors: ROTSTEIN, David Mark; (US).
YANG, Hanbiao; (US)
Agent: KJELLSAA-BERGER, Hanny; (CH)
Priority Data:
61/051,743 09.05.2008 US
Title (EN) HETEROCYCLIC ANTIVIRAL COMPOUNDS
(FR) COMPOSÉS HÉTÉROCYCLIQUES ANTIVIRAUX
Abstract: front page image
(EN)This invention relates to piperidine derivatives of formula (I) wherein R1, R2 and R3 are as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. Disorders that may be treated or prevented by the present derivatives include HIV and genetically related retroviral infections (and the resulting acquired immune deficiency syndrome, AIDS), rheumatoid arthritis, solid organ transplant reject (graft vs. host disease), asthma and COPR.
(FR)La présente invention concerne des dérivés de pipéridine de formule (I), dans laquelle: R1, R2 et R3 sont tels que définis dans la description utiles dans le traitement d’une variété de troubles, comprenant ceux dans lesquels la modulation des récepteurs CCR5 est impliquée. Les troubles pouvant être traités ou prévenus par les dérivés selon la présente invention comprennent le VIH et des infections rétrovirales génétiquement associées (et le syndrome d’immunodéficience acquis, SIDA), la polyarthrite rhumatoïde, le rejet de greffes d’organes solides (maladie du greffon contre l’hôte), l’asthme et la maladie pulmonaire obstructive chronique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)