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1. (WO2009135580) THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/135580    International Application No.:    PCT/EP2009/002606
Publication Date: 12.11.2009 International Filing Date: 08.04.2009
IPC:
C07D 333/38 (2006.01), C07D 495/04 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt (DE) (For All Designated States Except US).
CRAVO, Daniel [FR/FR]; (FR) (For US Only).
LEPIFRE, Franck [FR/FR]; (FR) (For US Only).
HALLAKOU-BOZEC, Sophie [FR/FR]; (FR) (For US Only).
CHARON, Christine [FR/FR]; (FR) (For US Only)
Inventors: CRAVO, Daniel; (FR).
LEPIFRE, Franck; (FR).
HALLAKOU-BOZEC, Sophie; (FR).
CHARON, Christine; (FR)
Priority Data:
08290423.6 05.05.2008 EP
Title (EN) THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
(FR) DÉRIVÉS DE THIÉNOPYRIDONE COMME ACTIVATEURS DE LA PROTÉINE KINASE ACTIVÉE PAR L’AMP (AMPK)
Abstract: front page image
(EN)The present invention relates to compounds of formula (I) wherein R1, R2 and B1, B2 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
(FR)La présente invention concerne des composés de formule (I) dans laquelle R1, R2 et B1, B2 sont tels que définis dans la revendication 1, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement et/ou la prévention de maladies et pathologies modulées par les agonistes de l’AMP. L’invention concerne également des intermédiaires et un procédé de préparation des composés de formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)