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1. (WO2009135184) METHODS FOR TREATING AND/OR PREVENTING CARDIOMYOPATHIES BY ERK OR JNK INHIBITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/135184    International Application No.:    PCT/US2009/042614
Publication Date: 05.11.2009 International Filing Date: 01.05.2009
IPC:
A61K 31/343 (2006.01), A61K 31/275 (2006.01), A61K 31/165 (2006.01), A61K 31/135 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 West 116th Street New York, NY 10027 (US) (For All Designated States Except US).
WORMAN, Howard, J. [US/US]; (US) (For US Only).
MUCHIR, Antoine [FR/US]; (US) (For US Only)
Inventors: WORMAN, Howard, J.; (US).
MUCHIR, Antoine; (US)
Agent: LOVE, Jane, M.; (US)
Priority Data:
61/049,462 01.05.2008 US
61/055,780 23.05.2008 US
Title (EN) METHODS FOR TREATING AND/OR PREVENTING CARDIOMYOPATHIES BY ERK OR JNK INHIBITION
(FR) PROCÉDÉS POUR TRAITER ET/OU EMPÊCHER DES CARDIOMYOPATHIES PAR INHIBITION D'ERK OU JNK
Abstract: front page image
(EN)Provided is a method of treating or preventing a cardiomyopathy associated with activation of at least one kinase in the MAP kinase signaling pathway in heart tissue by providing to a subject an inhibitor of at least one kinase in the ERK signaling pathway or in the JNK signaling pathway, or both. In some embodiments, the cardiomyopathy is associated with one or more mutations in the LMNA gene, which encodes A-type nuclear lamins, or in the EMD gene, which encodes an inner nuclear membrane protein.
(FR)L'invention concerne un procédé de traitement ou de prévention d'une cardiomyopathie associée à une activation d'au moins une kinase dans le trajet de signalisation de MAP kinase dans un tissu cardiaque en fournissant à un sujet un inhibiteur d'au moins une kinase dans le trajet de signalisation d'ERK ou dans le trajet de signalisation de JNK, ou les deux. Dans certains modes de réalisation, la cardiomyopathie est associée à une ou plusieurs mutations du gène LMNA, qui code pour des lamines nucléaires de type A, ou du gène EMD, qui code pour une protéine de membrane nucléaire intérieure.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)