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1. (WO2009134976) POTENT CONJUGATES AND HYDROPHILIC LINKERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134976    International Application No.:    PCT/US2009/042259
Publication Date: 05.11.2009 International Filing Date: 30.04.2009
IPC:
A61K 39/00 (2006.01)
Applicants: IMMUNOGEN, INC [US/US]; 830 Winter Street Waltham, MA 02451 (US) (For All Designated States Except US).
SINGH, Rajeeva [US/US]; (US) (For US Only).
KOVTUN, Yelena [US/US]; (US) (For US Only).
WILHELM, Sharon, D. [US/US]; (US) (For US Only).
CHARI, Ravi, V., J. [US/US]; (US) (For US Only)
Inventors: SINGH, Rajeeva; (US).
KOVTUN, Yelena; (US).
WILHELM, Sharon, D.; (US).
CHARI, Ravi, V., J.; (US)
Agent: MACK, Susan, J.; (US)
Priority Data:
61/049,289 30.04.2008 US
Title (EN) POTENT CONJUGATES AND HYDROPHILIC LINKERS
(FR) CONJUGUÉS PUISSANTS ET COUPLEURS HYDROPHILES
Abstract: front page image
(EN)Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment.
(FR)L'invention concerne des coupleurs pour lier des médicaments à des agents de liaison de cellule modifiés en coupleurs hydrophiles par incorporation d'un espaceur de polyéthylèneglycol. La puissance ou l'efficacité des conjugués d'agent de liaison à une cellule-médicament est renforcée de manière surprenante plusieurs fois dans divers types de cellules cancéreuses, y compris celles exprimant un faible nombre d'antigènes sur la surface cellulaire ou les cellules de cancer qui sont résistantes à un traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)