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Machine translation
1. (WO2009134956) CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE FORMULATIONS OF MODIFIED-RELEASE CALCIUM CHANNEL BLOCKER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134956    International Application No.:    PCT/US2009/042210
Publication Date: 05.11.2009 International Filing Date: 30.04.2009
IPC:
A61K 9/22 (2006.01), A61K 9/24 (2006.01)
Applicants: BLUE NOTE PHARMACEUTICALS, INC.; 70 Coons Road Troy, NY 12180 (US) (For All Designated States Except US).
RAFFANIELLO, Samn [US/US]; (US) (For US Only).
PETTI, Stephen, J. [US/US]; (US) (For US Only)
Inventors: RAFFANIELLO, Samn; (US).
PETTI, Stephen, J.; (US)
Agent: BROWN, William, M.; (US)
Priority Data:
61/125,914 30.04.2008 US
Title (EN) CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE FORMULATIONS OF MODIFIED-RELEASE CALCIUM CHANNEL BLOCKER
(FR) PRÉPARATIONS CHRONOTHÉRAPEUTIQUES D'UN INHIBITEUR DE CANAL CALCIQUE À LIBÉRATION MODIFIÉE ET ANTIHYPERTENSEUR
Abstract: front page image
(EN)The present invention relates to formulations of anti-hypertensive drugs. The present invention includes a modified-release formulation of diltiazem hydrochloride that is suitable for once-daily use and which provides delivery of drug either in the early morning hours, or overnight, so as to blunt the natural rise in blood pressure (BP) and heart rate (HR) in the morning and to reduce the slope of the increase in BP in patients with elevated BP (hypertension).
(FR)L'invention concerne des préparations de médicaments anti-hypertenseurs. La présente invention comprend une préparation à libération modifiée d'hydrochlorure de diltiazème qui est adaptée pour une utilisation une fois par jour et qui permet l'administration d'un médicament soit dans les premières heures du matin, soit toute une nuit, de manière à émousser la montée naturelle de la pression sanguine (PS) et de la fréquence cardiaque (FC) le matin et réduire la pente de l'augmentation de pression sanguine chez les patients ayant une pression sanguine élevée (hypertension).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)