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1. (WO2009134825) METAL COMPLEX PHOSPHATIDYL-INOSITOL-3-KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134825    International Application No.:    PCT/US2009/042012
Publication Date: 05.11.2009 International Filing Date: 29.04.2009
IPC:
A01N 43/00 (2006.01), A61K 31/00 (2006.01)
Applicants: THE TRUSTEES OF UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104-6283 (US) (For All Designated States Except US).
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US/US]; 3601 Spruce Street Philadelphia, PA 19104-4265 (US) (For All Designated States Except US).
MEGGERS, Eric [DE/DE]; (DE) (For US Only).
XIE, Peng [CN/US]; (US) (For US Only).
WILLIAMS, Douglas, S. [US/US]; (US) (For US Only).
MARMORSTEIN, Ronen [US/US]; (US) (For US Only)
Inventors: MEGGERS, Eric; (DE).
XIE, Peng; (US).
WILLIAMS, Douglas, S.; (US).
MARMORSTEIN, Ronen; (US)
Agent: CALDWELL, John, W.; (US)
Priority Data:
12/112,748 30.04.2008 US
Title (EN) METAL COMPLEX PHOSPHATIDYL-INOSITOL-3-KINASE INHIBITORS
(FR) INHIBITEURS, DE TYPE COMPLEXE MÉTALLIQUE, DE LA PHOSPHATIDYL-INOSITOL-3-KINASE
Abstract: front page image
(EN)Provided are novel organometallic compounds that inhibit P13K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.
(FR)La présente invention concerne des composés organométalliques inédits inhibant la lipide-kinase PI3K et la phospho-AKT dans les cellules du mélanome humain; lesdits composés inhibent aussi la migration des cellules du mélanome. La présente invention concerne également des procédés d'inhibition de la prolifération, de la migration ou de la prolifération et de la migration à la fois des cellules cancéreuses. Ces procédés comprennent la mise en contact d'une cellule cancéreuse avec un inhibiteur organométallique de la kinase décrit ici. L'invention concerne également des procédés de traitement d'une maladie ou d'une affection sur laquelle influe la kinase. Ces procédés de traitement comprennent l'administration à un sujet en ayant besoin d'une quantité efficace d'un point de vue thérapeutique d'un inhibiteur organométallique de la kinase décrit dans les présentes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)