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1. (WO2009134815) CANCELLOUS BONE TREATED WITH COLLAGENASE AND ESSENTIALLY FREE OF BLOOD CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134815    International Application No.:    PCT/US2009/041999
Publication Date: 05.11.2009 International Filing Date: 28.04.2009
IPC:
A61F 2/28 (2006.01)
Applicants: NUVASIVE, INC. [US/US]; 7475 Lusk Boulevard San Diego, CA 92121 (US) (For All Designated States Except US).
WILLIAMS, Michelle, LeRoux [US/US]; (US) (For US Only).
MILLS, Charles, Randal [US/US]; (US) (For US Only).
MONROY, Rodney [US/US]; (US) (For US Only).
ZAMBON, Robert, A. [US/US]; (US) (For US Only).
BUSKIRK, Dayna [US/US]; (US) (For US Only).
FENDER, Earl [US/US]; (US) (For US Only)
Inventors: WILLIAMS, Michelle, LeRoux; (US).
MILLS, Charles, Randal; (US).
MONROY, Rodney; (US).
ZAMBON, Robert, A.; (US).
BUSKIRK, Dayna; (US).
FENDER, Earl; (US)
Agent: BELL, Jay; Nuvasive, Inc. 7475 Lusk Boulevard San Diego, CA 92121 (US)
Priority Data:
12/150,513 28.04.2008 US
Title (EN) CANCELLOUS BONE TREATED WITH COLLAGENASE AND ESSENTIALLY FREE OF BLOOD CELLS
(FR) OS SPONGIEUX TRAITÉ PAR COLLAGÉNASE ET ESSENTIELLEMENT SANS CELLULES SANGUINES
Abstract: front page image
(EN)A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
(FR)L'invention concerne un implant osseux qui contient de l'os spongieux essentiellement exempt de cellules sanguines et traité avec au moins un agent de libération, par exemple de la collagénase ou une enzyme digestive, pendant une durée et à une concentration qui libèrent les cellules ostéogènes de la matrice de l'os spongieux. Les cellules ostéogènes de la matrice sont des cellules viables. Le traitement de l'os spongieux à l'aide d'au moins un agent de libération rend les cellules ostéogènes plus disponibles pour exécuter leur fonction ostéogène et augmenter la vitesse de formation d'os. Cet implant peut également contenir de l'os déminéralisé, par exemple de l'os cortical déminéralisé, qui renforce la capacité de régénération osseuse de l'os spongieux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)