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1. (WO2009134714) FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134714    International Application No.:    PCT/US2009/041796
Publication Date: 05.11.2009 International Filing Date: 27.04.2009
IPC:
C12N 9/22 (2006.01), C12Q 1/68 (2006.01)
Applicants: PRECISION BIOSCIENCES, INC. [US/US]; 104 T.W. Alexander Drive Bldg. 7 Research Triangle Park, NC 27709 (US) (For All Designated States Except US).
NICHOLSON, Michael, G. [US/US]; (US) (For US Only).
JANTZ, Derek [US/US]; (US) (For US Only).
SMITH, James, Jefferson [US/US]; (US) (For US Only)
Inventors: NICHOLSON, Michael, G.; (US).
JANTZ, Derek; (US).
SMITH, James, Jefferson; (US)
Agent: BAKER, Hollie, L.; (US)
Priority Data:
61/048,499 28.04.2008 US
Title (EN) FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
(FR) MOLÉCULES DE FUSION DE PROTÉINES DE LIAISON À L'ADN ET DE DOMAINES EFFECTEURS CONÇUS DE FAÇON RATIONNELLE
Abstract: front page image
(EN)Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain.
(FR)L'invention porte sur des effecteurs de transcription ciblés (activateurs et répresseurs de transcription) issus de méganucléases. L'invention porte également sur des acides nucléiques codant pour ceux-ci et sur des procédés d'utilisation de ceux-ci pour réguler l'expression génique. Les effecteurs de transcription ciblés peuvent comporter (i) un domaine de liaison à l'ADN de méganucléase n'ayant pas d'activité de clivage d'endonucléase qui se lie à un site de reconnaissance cible, et (ii) un domaine effecteur de transcription.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)