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Machine translation
1. (WO2009134668) 4-OXO-1,4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134668    International Application No.:    PCT/US2009/041493
Publication Date: 05.11.2009 International Filing Date: 23.04.2009
IPC:
C07D 471/04 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
KUDUK, Scott, D. [US/US]; (US) (For US Only).
DI MARCO, Christina, Ng [US/US]; (US) (For US Only).
SHIPE, William, D. [US/US]; (US) (For US Only)
Inventors: KUDUK, Scott, D.; (US).
DI MARCO, Christina, Ng; (US).
SHIPE, William, D.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US)
Priority Data:
61/126,085 01.05.2008 US
Title (EN) 4-OXO-1,4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
(FR) MODULATEURS ALLOSTÉRIQUES POSITIFS POUR LE RÉCEPTEUR M1 DE 4-OXO-1,4-DIHYDROQUINOLÉINE
Abstract: front page image
(EN)The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
(FR)La présente invention concerne des composés de formule (I) qui sont des modulateurs allostériques positifs pour le récepteur M1 et qui sont utiles dans le traitement de maladies dans lesquelles le récepteur M1 est impliqué, telles que la maladie d’Alzheimer, la schizophrénie, la douleur ou des troubles du sommeil. L’invention concerne en outre des compositions pharmaceutiques comprenant les composés, et l’utilisation des composés et compositions dans le traitement de maladies médiées par le récepteur M1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)