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1. (WO2009134387) CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/134387    International Application No.:    PCT/US2009/002633
Publication Date: 05.11.2009 International Filing Date: 30.04.2009
IPC:
C07D 413/10 (2006.01), C07D 413/14 (2006.01), A61K 31/5355 (2006.01), A61P 19/10 (2006.01)
Applicants: VITAE PHARMACEUTICALS, INC. [US/US]; 502 West Office Center Drive Fort Washington, PA 19034 (US) (For All Designated States Except US).
BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173 55216 Ingelheim Am Rhein (DE) (For All Designated States Except US).
CLAREMON, David, A. [US/US]; (US) (For US Only).
ZHUANG, Linghang [CN/US]; (US) (For US Only).
LEFTHERIS, Katerina [US/US]; (US) (For US Only).
TICE, Colin, M. [US/US]; (US) (For US Only).
YE, Yuanjie [CN/US]; (US) (For US Only).
SINGH, Suresh, B. [US/US]; (US) (For US Only).
HIMMELSBACH, Frank [DE/DE]; (DE) (For US Only)
Inventors: CLAREMON, David, A.; (US).
ZHUANG, Linghang; (US).
LEFTHERIS, Katerina; (US).
TICE, Colin, M.; (US).
YE, Yuanjie; (US).
SINGH, Suresh, B.; (US).
HIMMELSBACH, Frank; (DE)
Agent: DAVIS, Steven, G.; (US)
Priority Data:
61/137,148 25.07.2008 US
61/206,817 04.02.2009 US
PCT/US2008/009017 25.07.2008 US
61/049,650 01.05.2008 US
Title (EN) CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
(FR) INHIBITEURS CYCLIQUES DE LA 11-BÊTA-HYDROXYSTÉROÏDE DÉHYDROGÉNASE 1
Abstract: front page image
(EN)This invention relates to novel compounds of the Formula I1 Ik, Im3, Im4, Im6-12, In3, In4, In6-12, lo3, lo4, lo6-12, Ip2, Ip4-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
(FR)La présente invention concerne de nouveaux composés de formule I1 Ik, Im3, Im4, Im6-12, In3, In4, In6-12, lo3, lo4, lo6-12, Ip2, Ip4-7, leurs sels pharmaceutiquement acceptables, et leurs compositions pharmaceutiques, qui sont utiles pour le traitement thérapeutique de pathologies associées à la modulation ou à l’inhibition de la 11-β-HSD1 chez les mammifères. L’invention concerne en outre des compositions pharmaceutiques des nouveaux composés et leurs méthodes d’utilisation dans la réduction ou la régulation de la production de cortisol dans une cellule ou l’inhibition de la conversion de la cortisone en cortisol dans une cellule.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)