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Pub. No.:    WO/2009/134203    International Application No.:    PCT/SE2009/050464
Publication Date: 05.11.2009 International Filing Date: 30.04.2009
Chapter 2 Demand Filed:    26.02.2010    
C07D 513/14 (2006.01), A61K 31/549 (2006.01), A61P 11/00 (2006.01), A61P 25/28 (2006.01), A61P 31/04 (2006.01), A61P 9/00 (2006.01), A61K 31/437 (2006.01), C07D 471/04 (2006.01)
Applicants: ALMQVIST, Fredrik [SE/SE]; (SE).
SELLSTEDT, Magnus [SE/SE]; (SE) (For US Only).
DAS, Pralay [IN/IN]; (IN) (For US Only)
Inventors: ALMQVIST, Fredrik; (SE).
SELLSTEDT, Magnus; (SE).
DAS, Pralay; (IN)
Agent: ALBIHNS AB; P.O Box 5581 Valhallavägen 117 S-114 85 Stockholm (SE)
Priority Data:
61/048,976 30.04.2008 US
Abstract: front page image
(EN)The present invention relates to new compounds of the formula (I), (II), or (III)wherein R1, R2, R3, R4, R5 and W are as defined herein, and pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloid disease, such as observed in Alzheimer's disease, infectious diseases, PAI-I related disease, and in the manufacture of medicaments for such treatment.
(FR)La présente invention concerne de nouveaux composés de formule (I), (II) ou (III) dans lesquelles R1, R2, R3, R4, R5 et W sont tels que définis dans la description, et des compositions pharmaceutiques les contenant, et leur utilisation dans le traitement des amyloses, en particulier l’amylose Aβ, telles qu’observées dans la maladie d’Alzheimer, des maladies infectieuses, une maladie liée au PAI-I, et dans la fabrication de médicaments destinés à ce traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)