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1. (WO2009134110) 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/134110 International Application No.: PCT/LT2008/000003
Publication Date: 05.11.2009 International Filing Date: 18.06.2008
IPC:
C07D 285/06 (2006.01) ,A61K 31/433 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
285
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01
Five-membered rings
02
Thiadiazoles; Hydrogenated thiadiazoles
04
not condensed with other rings
06
1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
433
Thiadiazoles
Applicants:
BIOTECHNOLOGIJOS INSTITUTAS [LT/LT]; V. Graiciuno g. 8 LT-02241 Vilnius, LT (AllExceptUS)
MATULIS, Daumantas [LT/LT]; LT (UsOnly)
CIKOTIENE, Inga [LT/LT]; LT (UsOnly)
KAZLAUSKAS, Egidijus [LT/LT]; LT (UsOnly)
MATULIENE, Jurgita [LT/LT]; LT (UsOnly)
Inventors:
MATULIS, Daumantas; LT
CIKOTIENE, Inga; LT
KAZLAUSKAS, Egidijus; LT
MATULIENE, Jurgita; LT
Agent:
GERASIMOVIC, Liudmila; Vingriu g. 13-42 LT-01141 Vilnius, LT
Priority Data:
2008 03530.04.2008LT
Title (EN) 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF
(FR) 5-ARYL-4-(2,4-DIHYDROXYPHÉNYL-5-SUBSTITUÉ)-1,2,3-THIADIAZOLES UTILISÉS EN TANT QU'INHIBITEURS DE LA PROTÉINE CHAPERON HSP90 ET INTERMÉDIAIRES POUR LA PRÉPARATION DE CEUX-CI
Abstract:
(EN) Invention is related to novel compounds - 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles with general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit Hsp90 chaperone which participate in cancer progression. This invention is also related to new intermediate compounds which are used for the synthesis of thiadiazoles of general formula (I).
(FR) La présente invention concerne de nouveaux composés 5-aryl-4-(2,4-dihydroxyphényl-5-substitué)-1,2,3-thiadiazoles de formule générale (I). Les composés peuvent être utilisés en biomédecine en tant qu'ingrédients dans des formulations pharmaceutiques, parce qu'ils inhibent la protéine chaperon HSP90 qui participe à la progression du cancer. Cette invention concerne en outre de nouveaux composés intermédiaires qui sont utilisés pour la synthèse de thiadiazoles de formule générale (I).
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2268626US20110046387