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1. (WO2009133939) AGENT FOR RECRUITMENT OF BONE-MARROW-DERIVED PLURIPOTENT STEM CELL INTO PERIPHERAL CIRCULATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/133939    International Application No.:    PCT/JP2009/058515
Publication Date: 05.11.2009 International Filing Date: 30.04.2009
IPC:
A61K 38/00 (2006.01), A61K 35/76 (2006.01), A61K 48/00 (2006.01), A61P 17/02 (2006.01), A61P 43/00 (2006.01), C07K 14/435 (2006.01), C12N 5/10 (2006.01), C12N 15/09 (2006.01), C12Q 1/02 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: GENOMIX CO., LTD. [JP/JP]; 3FL, Saito Biotechnology Incubator, 7-15, Saito-Asagi 7-chome, Ibaraki-shi, Osaka 5670085 (JP) (For All Designated States Except US).
OSAKA UNIVERSITY [JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871 (JP) (For All Designated States Except US).
TAMAI, Katsuto [JP/JP]; (JP) (For US Only).
YAMAZAKI, Takehiko [JP/JP]; (JP) (For US Only).
CHINO, Takenao [JP/JP]; (JP) (For US Only).
KANEDA, Yasufumi [JP/JP]; (JP) (For US Only)
Inventors: TAMAI, Katsuto; (JP).
YAMAZAKI, Takehiko; (JP).
CHINO, Takenao; (JP).
KANEDA, Yasufumi; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2008-119348 30.04.2008 JP
Title (EN) AGENT FOR RECRUITMENT OF BONE-MARROW-DERIVED PLURIPOTENT STEM CELL INTO PERIPHERAL CIRCULATION
(FR) AGENT DE RECRUTEMENT D'UNE CELLULE SOUCHE PLURIPOTENTE ISSUE DE LA MOELLE OSSEUSE DANS LA CIRCULATION PÉRIPHÉRIQUE
(JA) 末梢循環への骨髄由来多能性幹細胞動員薬
Abstract: front page image
(EN)The following facts 1) to 3) are found; 1) when a tissue extract which is extracted from an isolated skin graft is administered intravenously, a bone-marrow-derived pluripotent stem cell can be induced in a peripheral blood; 2) the substance which can recruit the bone-marrow-derived pluripotent stem cell contained in the isolated skin graft into the peripheral blood is HMGB1; and 3) HMGB1 which has an activity to recruit the bone-marrow-derived pluripotent stem cell into the peripheral blood can be purified readily from cells in culture.
(FR)La présente invention concerne les faits suivants 1) à 3) : 1) lorsqu'un extrait de tissu qui est extrait d'une greffe de peau isolée est administré par voie intraveineuse, une cellule souche pluripotente issue de moelle osseuse peut être induite dans un sang périphérique; 2) la substance qui peut recruter la cellule souche pluripotente issue de moelle osseuse contenue dans la greffe de peau isolée dans le sang périphérique est HMGB1, et 3) HMGB1 qui a une activité pour recruter la cellule souche pluripotente issue de moelle osseuse dans le sang périphérique peut être purifiée rapidement à partir de cellules en culture.
(JA) 本発明は、1)遊離皮膚片から抽出される組織抽出液を静脈内に投与することで、末梢血中に骨髄由来多能性組織幹細胞を誘導し、2)さらに遊離皮膚片中の骨髄由来多能性組織幹細胞を末梢血中に動員する物質はHMGB1であること、3)骨髄由来多能性幹細胞を末梢血中に動員する活性を有するHMGB1は培養細胞から簡便に精製できることを世界で初めて明らかにした。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)