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1. (WO2009133915) CANCER MARKER, METHOD FOR EVALUATION OF CANCER BY USING THE CANCER MARKER, AND EVALUATION REAGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/133915    International Application No.:    PCT/JP2009/058421
Publication Date: 05.11.2009 International Filing Date: 28.04.2009
IPC:
C12Q 1/68 (2006.01), C12N 15/09 (2006.01)
Applicants: NEC Corporation [JP/JP]; 7-1, Shiba 5-chome Minato-ku, Tokyo 1088001 (JP) (For All Designated States Except US).
TOKYO MEDICAL UNIVERSITY [JP/JP]; 6-1-1, Shinjuku, Shinjuku-ku, Tokyo 1608402 (JP) (For All Designated States Except US).
KURODA Masahiko [JP/JP]; (JP).
TANAKA Masami; (For US Only).
OIKAWA Kosuke; (For US Only).
MIZUTANI Takayuki; (For US Only).
TAKANASHI Masakatsu; (For US Only).
IIZUKA Seiko; (For US Only).
KOSUGI Yoshinori; (For US Only).
OHYASHIKI Kazuma; (For US Only).
TSUCHIDA Akihiko; (For US Only)
Inventors: KURODA Masahiko; (JP).
TANAKA Masami; .
OIKAWA Kosuke; .
MIZUTANI Takayuki; .
TAKANASHI Masakatsu; .
IIZUKA Seiko; .
KOSUGI Yoshinori; .
OHYASHIKI Kazuma; .
TSUCHIDA Akihiko;
Agent: TSUJIMARU Koichiro; (JP)
Priority Data:
2008-119280 30.04.2008 JP
Title (EN) CANCER MARKER, METHOD FOR EVALUATION OF CANCER BY USING THE CANCER MARKER, AND EVALUATION REAGENT
(FR) MARQUEUR DE CANCER, PROCÉDÉ D’ÉVALUATION DU CANCER UTILISANT LE MARQUEUR DE CANCER ET RÉACTIF D’ÉVALUATION
(JA) 癌マーカー、それを用いた癌の評価方法および評価試薬
Abstract: front page image
(EN)Disclosed is a novel cancer marker for evaluating the onset, preclinical stage, clinical stage or prognosis of cancer in a subject.  Also disclosed is an evaluation method using the cancer marker.  A cancer marker comprising at least one miRNA selected from hsa-miR-92 and hsa-miR-494 can be used as a marker for all types of cancer excluding breast cancer.  A method for evaluating the possibility of the occurrence of cancer other than breast cancer in a subject involves a cancer marker detection step of detecting the expression level of a cancer marker in a biological sample collected from the subject, wherein the cancer marker comprises at least one miRNA selected from hsa-miR-92 and hsa-miR-494.
(FR)La présente invention concerne un nouveau marqueur de cancer pour évaluer l’apparition, le stade préclinique, le stade clinique ou le pronostic d’un cancer chez un sujet. La présente invention concerne en outre un procédé d’évaluation utilisant le marqueur de cancer. Un marqueur de cancer comprenant au moins un ARNmi choisi parmi hsa-miR-92 et hsa-miR-494 peut être utilisé en tant que marqueur pour tous les types de cancer à l’exception du cancer du sein. Un procédé pour évaluer la possibilité de l’occurrence d’un cancer autre qu’un cancer du sein chez un sujet met en œuvre une étape de détection de marqueur de cancer pour détecter le taux d’expression d’un marqueur de cancer dans un échantillon biologique collecté sur le sujet, où le marqueur de cancer comprend au moins un ARNmi choisi parmi hsa-miR-92 et hsa-miR-494.
(JA) 被検者の癌の発症、前臨床期、臨床期または予後を評価するための新規な癌マーカーおよびそれを用いた評価方法を提供する。hsa-miR-92およびhsa-miR-494の少なくとも一方のmiRNAを含む癌マーカーを、乳癌を除く癌のマーカーとする。乳癌を除く癌の可能性を評価する方法は、被検者から採取した生体試料における癌マーカーの発現レベルを検出する癌マーカー検出工程を含み、前記癌マーカーが、hsa-miR-92およびhsa-miR-494の少なくとも一方のmiRNAを含む癌マーカーであることを特徴とする。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)