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1. (WO2009133905) PEPTIDE CAPABLE OF INHIBITING ACTIVITY OF HUMAN FIBROBLAST GROWTH FACTOR-23 (HUMAN FGF-23), AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/133905    International Application No.:    PCT/JP2009/058403
Publication Date: 05.11.2009 International Filing Date: 28.04.2009
IPC:
C07K 7/64 (2006.01), A61K 38/22 (2006.01), A61P 3/02 (2006.01), A61P 3/12 (2006.01), A61P 3/14 (2006.01), A61P 5/00 (2006.01), A61P 5/18 (2006.01), A61P 5/20 (2006.01), A61P 13/12 (2006.01), A61P 17/04 (2006.01), A61P 19/08 (2006.01), A61P 19/10 (2006.01), A61P 21/00 (2006.01), A61P 35/00 (2006.01), C07K 19/00 (2006.01), C12N 15/09 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: Kyowa Hakko Kirin Co., Ltd. [JP/JP]; 1-6-1, Ohtemachi, Chiyoda-ku, Tokyo 1008185 (JP) (For All Designated States Except US).
URAKAWA Itaru [JP/JP]; (JP) (For US Only).
YAMAZAKI Yuji [JP/JP]; (JP) (For US Only).
YAMASHITA Takeyoshi [JP/JP]; (JP) (For US Only)
Inventors: URAKAWA Itaru; (JP).
YAMAZAKI Yuji; (JP).
YAMASHITA Takeyoshi; (JP)
Agent: HIRAKI Yusuke; (JP)
Priority Data:
2008-117661 28.04.2008 JP
Title (EN) PEPTIDE CAPABLE OF INHIBITING ACTIVITY OF HUMAN FIBROBLAST GROWTH FACTOR-23 (HUMAN FGF-23), AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
(FR) PEPTIDE CAPABLE D’INHIBER L’ACTIVITÉ DU FACTEUR DE CROISSANCE DES FIBROBLASTES 23 HUMAIN (FGF-23 HUMAIN), ET COMPOSITION PHARMACEUTIQUE COMPRENANT CELUI-CI
(JA) ヒト線維芽細胞増殖因子23(ヒトFGF23)の作用を抑制するペプチドおよびそれを含む医薬組成物
Abstract: front page image
(EN)Disclosed is a pharmaceutical composition for the treatment or prevention of a disease which can be prevented or treated through the inhibition of the activity of human FGF-23 protein. Specifically disclosed is a peptide comprising an amino acid sequence represented by the formula: X1X2ProX3X4X3X3X5X6X7 [wherein X1 represents serine, threonine, arginine or lysine; X2 represents aspartic acid or glutamic acid; three X3’s independently represent valine, leucine or isoleucine; X4 represents glycine, alanine, asparagine or glutamine; X5 represents lysine or arginine; X6 represents glycine, alanine or proline; and X7 represents glycine, alanine, arginine or lysine].
(FR)La présente invention concerne une composition pharmaceutique pour le traitement ou la prévention d’une maladie qui peut être prévenue ou traitée par l’inhibition de l’activité de la protéine FGF-23 humaine. La présente invention concerne spécifiquement un peptide comprenant une séquence d’acides aminés représentée par la formule : X1X2ProX3X4X3X3X5X6X7 [dans laquelle X1 représente la sérine, la thréonine, l’arginine ou la lysine ; X2 représente l’acide aspartique ou l’acide glutamique ; les trois X3 représentent indépendamment la valine, la leucine ou l’isoleucine ; X4 représente la glycine, l’alanine, l’asparagine ou la glutamine ; X5 représente la lysine ou l’arginine ; X6 représente la glycine, l’alanine ou la proline ; et X7 représente la glycine, l’alanine, l’arginine ou la lysine].
(JA) ヒトFGF23タンパク質の作用を抑制することにより予防または治療が可能な疾患に対する治療または予防のための医薬品組成物の提供。  X12ProX3433567[ここで、X1はセリン、トレオニン、アルギニンまたはリジンであり、X2はアスパラギン酸またはグルタミン酸であり、3つのX3は独立にバリン、ロイシンまたはイソロイシンであり、X4はグリシン、アラニン、アスパラギンまたはグルタミンであり、X5はリジンまたはアルギニンであり、X6はグリシン、アラニンまたはプロリンであり、X7はグリシン、アラニン、アルギニンまたはリジン]で表されるアミノ酸配列からなるペプチド。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)