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1. (WO2009133831) PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/133831    International Application No.:    PCT/JP2009/058240
Publication Date: 05.11.2009 International Filing Date: 27.04.2009
IPC:
C07D 231/56 (2006.01), A61K 31/416 (2006.01), A61K 31/4178 (2006.01), A61K 31/422 (2006.01), A61K 31/427 (2006.01), A61P 1/04 (2006.01), A61P 1/16 (2006.01), A61P 1/18 (2006.01), A61P 9/10 (2006.01), A61P 11/06 (2006.01), A61P 17/02 (2006.01), A61P 19/02 (2006.01), A61P 19/06 (2006.01), A61P 19/08 (2006.01), A61P 25/02 (2006.01), A61P 25/08 (2006.01), A61P 25/16 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 27/06 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61P 35/04 (2006.01), A61P 37/02 (2006.01), A61P 37/06 (2006.01), A61P 37/08 (2006.01), A61P 43/00 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01), C07D 411/12 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01)
Applicants: ASAHI KASEI PHARMA CORPORATION [JP/JP]; 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo 1018101 (JP) (For All Designated States Except US).
MORITA Kohei [JP/JP]; (JP) (For US Only).
KURIYAMA Hiroshi [JP/JP]; (JP) (For US Only).
TANAKA Kosuke [JP/JP]; (JP) (For US Only)
Inventors: MORITA Kohei; (JP).
KURIYAMA Hiroshi; (JP).
TANAKA Kosuke; (JP)
Agent: SIKs & Co.; 8th Floor, Kyobashi-Nisshoku Bldg., 8-7, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031 (JP)
Priority Data:
61/048,346 28.04.2008 US
Title (EN) PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF
(FR) DÉRIVÉ D’ACIDE PHÉNYLPROPIONIQUE ET SON UTILISATION
(JA) フェニルプロピオン酸誘導体及びその用途
Abstract: front page image
(EN)Disclosed is a compound represented by general formula (1) (wherein X represents a halogen atom, an optionally substituted alkyl group or the like; Y represents a hydrogen atom or an optionally substituted alkyl group; and Z represents a hydrogen atom or an optionally substituted alkyl group) or a salt thereof.  The compound has excellent 4-type PLA2 inhibitory activity, and thus exhibits prostaglandin and/or leukotriene production inhibitory activity.
(FR)La présente invention concerne un composé représenté par la formule générale (1) (dans laquelle X représente un atome d’halogène, un groupe alkyle facultativement substitué ou similaire ; Y représente un atome d’hydrogène ou un groupe alkyle facultativement substitué ; et Z représente un atome d’hydrogène ou un groupe alkyle facultativement substitué) ou son sel. Le composé présente une excellente activité inhibitrice de la phospholipase A2 (PLA2) de type IV, et présente donc une activité inhibitrice des prostaglandines et/ou des leucotriènes.
(JA) 優れた4型PLA2阻害活性によりプロスタグランジン及び/又はロイコトリエンの産生抑制作用を有する下記一般式(1)[Xはハロゲン原子、置換されていてもよいアルキル基等を示し、Yは水素原子又は置換されていてもよいアルキル基を示し、Zは水素原子又は置換されていてもよいアルキル基を示す。]で示される化合物又はその塩:
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)