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Machine translation
1. (WO2009133137) PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/133137    International Application No.:    PCT/EP2009/055194
Publication Date: 05.11.2009 International Filing Date: 29.04.2009
IPC:
A61K 47/48 (2006.01), A61P 43/00 (2006.01)
Applicants: ASCENDIS PHARMA AS [DK/DK]; Tuborg Boulevard 12 DK-2900 Hellerup (DK) (For All Designated States Except US).
RAU, Harald [DE/DE]; (DE) (For US Only).
KINDERMANN, Susanne [DE/DE]; (DE) (For US Only).
LESSMANN, Torben [DE/DE]; (DE) (For US Only).
NØRSKOV RASMUSSEN, Grethe [DK/DK]; (DK) (For US Only).
HERSEL, Ulrich [DE/DE]; (DE) (For US Only).
WEGGE, Thomas [DE/DE]; (DE) (For US Only).
SPROGØE, Kennett [DK/US]; (US) (For US Only)
Inventors: RAU, Harald; (DE).
KINDERMANN, Susanne; (DE).
LESSMANN, Torben; (DE).
NØRSKOV RASMUSSEN, Grethe; (DK).
HERSEL, Ulrich; (DE).
WEGGE, Thomas; (DE).
SPROGØE, Kennett; (US)
Agent: BÜCHEL, Edwin; Isenbruck Bösl Hörschler LLP Patentanwälte EASTSITE ONE Seckenheimer Landstrasse 4 68163 Mannheim (DE)
Priority Data:
08155408.1 29.04.2008 EP
08162865.3 22.08.2008 EP
08167289.1 22.10.2008 EP
Title (EN) PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS
(FR) COMPOSÉS D'HORMONE DE CROISSANCE HUMAINE RECOMBINANTS PEGYLÉS
Abstract: front page image
(EN)A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
(FR)L'invention concerne une hormone de croissance humaine modifiée chimiquement (rhGH) préparée par fixation d'un lieur transitoire qui comprend un polyéthylène glycol. La protéine chimiquement modifiée peut avoir une activité rhGH durant bien plus longtemps que celle de la rhGH non modifiée, permettant des opportunités de dose réduite et de programme réduit et la rhGH modifiée ne peut pas provoquer de lipoatrophie. L'invention porte également sur des procédés d'utilisation pour le traitement et/ou la prévention de maladies ou de troubles dans lesquels l'utilisation d'hormone de croissance est utile.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)