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Pub. No.:    WO/2009/132980    International Application No.:    PCT/EP2009/054638
Publication Date: 05.11.2009 International Filing Date: 20.04.2009
Chapter 2 Demand Filed:    16.11.2009    
C07D 471/04 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
BROOKFIELD, Frederick [GB/GB]; (GB) (For US Only).
DILLON, Michael, Patrick [GB/US]; (US) (For US Only).
EUSTACHE, Florence [FR/GB]; (GB) (For US Only).
GOLDSTEIN, David, Michael [US/US]; (US) (For US Only).
GONG, Leyi [US/US]; (US) (For US Only).
HAN, Xiaochun [CN/US]; (US) (For US Only).
HOGG, Joan, Heather [CA/US]; (US) (For US Only).
PARK, Jaehyeon [KR/US]; (US) (For US Only).
REUTER, Deborah, Carol [US/US]; (US) (For US Only).
SJOGREN, Eric, Brian [US/US]; (US) (For US Only)
Inventors: BROOKFIELD, Frederick; (GB).
DILLON, Michael, Patrick; (US).
EUSTACHE, Florence; (GB).
GOLDSTEIN, David, Michael; (US).
GONG, Leyi; (US).
HAN, Xiaochun; (US).
HOGG, Joan, Heather; (US).
PARK, Jaehyeon; (US).
REUTER, Deborah, Carol; (US).
SJOGREN, Eric, Brian; (US)
Agent: HEIROTH, Ulrike; (CH)
Priority Data:
61/048,574 29.04.2008 US
Abstract: front page image
(EN)This application discloses novel pyrimidinyl pyridone derivatives according to formula (I), wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula (I) and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
(FR)L'invention concerne de nouveaux dérivés de pyrimidinyle pyridone de la formule (I), dans laquelle A, R1, R2, R3, et m sont tels que définis dans la description, qui inhibent JNK. Les composés selon l'invention sont utiles pour moduler l'activité de JNK et traiter les maladies associées à une activité JNK excessive. Lesdits composés permettent de traiter les maladies autoimmunes, inflammatoires, métaboliques et neurologique et le cancer. L'invention se rapporte aussi à des compositions renfermant le composé de la formule (I) et à des procédés de traitement qui consistent à administrer une quantité thérapeutiquement efficace du composé de la formule I à un sujet qui en a besoin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)