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1. (WO2009132593) QUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/132593    International Application No.:    PCT/CN2009/071573
Publication Date: 05.11.2009 International Filing Date: 29.04.2009
IPC:
C07D 215/233 (2006.01), C07D 215/20 (2006.01), A61K 31/47 (2006.01), A61P 3/06 (2006.01)
Applicants: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY [CN/CN]; No. 1320 Beijing Road (W) Shanghai 200040 (CN) (For All Designated States Except US).
CAI, Zhengyan [CN/CN]; (CN) (For US Only).
ZHOU, Weicheng [CN/CN]; (CN) (For US Only).
HAO, Qun [CN/CN]; (CN) (For US Only).
SHI, Zhenhua [CN/CN]; (CN) (For US Only).
SHENG, Yuchen [CN/CN]; (CN) (For US Only).
SHI, Mingyu [CN/CN]; (CN) (For US Only).
LIANG, Qingning [CN/CN]; (CN) (For US Only)
Inventors: CAI, Zhengyan; (CN).
ZHOU, Weicheng; (CN).
HAO, Qun; (CN).
SHI, Zhenhua; (CN).
SHENG, Yuchen; (CN).
SHI, Mingyu; (CN).
LIANG, Qingning; (CN)
Agent: SHANGHAI ZHI XIN PATENT AGENT LTD.; 26/F, Zhijun Buliding,No.1223 Xietu Road Shanghai 200032 (CN)
Priority Data:
200810036930.7 30.04.2008 CN
Title (EN) QUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
(FR) COMPOSÉS QUINOLINE, COMPOSITIONS PHARMACEUTIQUES, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS ASSOCIÉS
(ZH) 喹啉类化合物及其药物组合物、制备方法和应用
Abstract: front page image
(EN)Quinoline compounds represented by formula A, pharmaceutically acceptable solvates, optical isomers or polymorphs thereof, wherein X is S or O, M is H, Na+, NH4+ or Ca2+; each of R1, R2 and R3 is independently H, halo, the substituent represented by formula D or E; R is H, halo, C1-C4 alkyl or C1-C4 alkoxy. Also disclosed are the pharmaceutical compositions and preparation methods of these compounds and the uses of these compounds for the manufacture of medicaments for inhibiting HMG CoA reductase or for the treatment and prophylaxis of the diseases which can be treated effectively by inhibiting HMG CoA reductase. The present quinoline compounds and their pharmaceutical compositions have an excellent lipid reduction effect in vivo and can be used for the treatment of the diseases relating to hyperlipidemia.
(FR)La présente invention concerne des composés quinoline représentés par la formule A, leurs solvats, isomères optiques ou polymorphes de qualité pharmaceutique, dans laquelle X est S ou O, M est H, Na+, NH4+ ou Ca2+, R1, R2 et R3 sont chacun indépendamment H, halo, le substituant représenté par la formule D ou E, R est H, halo, alkyle en C1-C4 ou alcoxy en C1-C4. L’invention concerne également des compositions pharmaceutiques et des procédés de préparation de ces composés et des utilisations de ces composés pour la fabrication de médicaments permettant l’inhibition de la HMG CoA réductase ou le traitement et la prophylaxie de maladies qui peuvent être traitées efficacement par l’inhibition de la HMG CoA réductase. Les composés quinoline de la présente invention et leurs compositions pharmaceutiques permettent de réduire admirablement le taux de lipides dans le sang in vivo et peuvent être utilisés pour le traitement de maladies liées à l’hyperlipidémie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)