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1. (WO2009132253) USE OF EPOTHELONE D IN TREATING TAU-ASSOCIATED DISEASES INCLUDING ALZHEIMER'S DISEASE

Pub. No.:    WO/2009/132253    International Application No.:    PCT/US2009/041634
Publication Date: Oct 29, 2009 International Filing Date: Apr 24, 2009
IPC: A61K 31/427
A61P 25/00
A61P 25/16
A61P 25/28
A61P 27/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
ALBRIGHT, Charles, F.
BARTEN, Donna, Marie
LEE, Francis, Y.
Inventors: ALBRIGHT, Charles, F.
BARTEN, Donna, Marie
LEE, Francis, Y.
Title: USE OF EPOTHELONE D IN TREATING TAU-ASSOCIATED DISEASES INCLUDING ALZHEIMER'S DISEASE
Abstract:
Methods of treating Tau-associated diseases, preferably tauopathies, are described using epothilone D that exhibit good brain penetration, long half- life, and high selective retention in brain, and provides effective therapies in treating tauopathies including Alzheimer's disease.