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1. (WO2009132123) CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/132123    International Application No.:    PCT/US2009/041432
Publication Date: 29.10.2009 International Filing Date: 22.04.2009
IPC:
C07D 487/04 (2006.01), A61K 31/395 (2006.01), A61K 31/41 (2006.01), A61K 31/4188 (2006.01), C07H 19/23 (2006.01), A61K 31/7052 (2006.01), A61P 31/12 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive Foster City, CA 94404 (US) (For All Designated States Except US).
CHO, Aesop [US/US]; (US) (For US Only).
KIM, Choung, U. [US/US]; (US) (For US Only).
PARRISH, Jay [US/US]; (US) (For US Only).
XU, Jie [US/US]; (US) (For US Only)
Inventors: CHO, Aesop; (US).
KIM, Choung, U.; (US).
PARRISH, Jay; (US).
XU, Jie; (US)
Agent: WARD, John; (US)
Priority Data:
61/047,263 23.04.2008 US
61/139,449 19.12.2008 US
Title (EN) CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
(FR) ANALOGUES DE CARBA-NUCLÉOSIDE POUR UN TRAITEMENT ANTIVIRAL
Abstract: front page image
(EN)Provided are imidazol [1,5-f] [1,2.4]triazinyl, imidazol [1,2,4]triazinyl, and [1,2,4] triazolo [4,3-f] [1,2,4] triazinyl nucleosides of formula I nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Wherein X1 or X2 is indepently C-R10 or N and wherein at least one of X1 or X2 is N.
(FR)L'invention porte sur des imidazol [1,5-f] [1,2,4]triazinyl, imidazol [1,2,4]triazinyl, et [1,2,4] triazolo [4,3-f] [1,2,4] triazinyl nucléosides de formule I1, sur des nucléosides phosphates et promédicaments de ceux-ci. Les composés, compositions et procédés sont utiles pour le traitement d'infections par un virus de la famille Flaviviridae, en particulier des infections de l'hépatite C. Dans la formule, X1 ou X2 est indépendamment C-R10 ou N et au moins l'un de X1 ou X2 est N.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)