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1. WO2009131958 - COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING TRIAZINE DERIVATIVES

Publication Number WO/2009/131958
Publication Date 29.10.2009
International Application No. PCT/US2009/041165
International Filing Date 20.04.2009
IPC
A01N 43/64 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
64having rings with three nitrogen atoms as the only ring hetero atoms
A61K 31/53 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
CPC
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
C07D 253/065
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
253Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
02not condensed with other rings
061,2,4-Triazines
065having three double bonds between ring members or between ring members and non-ring members
C07D 253/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
253Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
02not condensed with other rings
061,2,4-Triazines
065having three double bonds between ring members or between ring members and non-ring members
07with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 409/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • INSTITUTE FOR ONEWORLD HEALTH [US]/[US] (AllExceptUS)
  • RUSSELL, Michael, Geoffrey Neil [GB]/[GB] (UsOnly)
  • PEACH, Joanne [GB]/[GB] (UsOnly)
  • MACRITCHIE, Jacqueline, Anne [GB]/[GB] (UsOnly)
  • BRUCKNER, Sebastian [GB]/[GB] (UsOnly)
  • DOYLE, Kevin, James [GB]/[GB] (UsOnly)
Inventors
  • RUSSELL, Michael, Geoffrey Neil
  • PEACH, Joanne
  • MACRITCHIE, Jacqueline, Anne
  • BRUCKNER, Sebastian
  • DOYLE, Kevin, James
Agents
  • KONSKI, Antoinette, F.
Priority Data
61/046,78321.04.2008US
61/098,53919.09.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING TRIAZINE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS À BASE DE DÉRIVÉS DE TRIAZINE
Abstract
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) La présente invention concerne des compositions et procédés destinés au traitement d'une maladie affectant un animal, laquelle maladie répond favorablement au blocage du peptide fonctionnel régulateur de la conductance transmembranaire de la fibrose kystique ou "CFTR" (Cystic Fibrosis Transmembrane conductance Regulator) par administration, à un mammifère justifiant d'un tel traitement, d'une quantité suffisante d'un composé tel que défini dans la présente demande, y-compris les composés présentés dans le Tableau 1 ou pris en considération par les Formules (I) et (II), ou de compositions comprenant ces composés, ce qui permet de traiter la maladie. La présente invention concerne en particulier un procédé permettant de traiter la diarrhée et la polykystose rénale.
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