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1. WO2009131956 - COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING TRIAZOLE DERIVATIVES

Publication Number WO/2009/131956
Publication Date 29.10.2009
International Application No. PCT/US2009/041162
International Filing Date 20.04.2009
IPC
A01N 43/64 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
64having rings with three nitrogen atoms as the only ring hetero atoms
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
C07D 249/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • INSTITUTE FOR ONEWORLD HEALTH [US]/[US] (AllExceptUS)
  • RUSSELL, Michael, Geoffrey Neil [GB]/[GB] (UsOnly)
  • DOYLE, Kevin, James [GB]/[GB] (UsOnly)
Inventors
  • RUSSELL, Michael, Geoffrey Neil
  • DOYLE, Kevin, James
Agents
  • KONSKI, Antoinette, F.
Priority Data
61/046,78021.04.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING TRIAZOLE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS DE TRIAZOLE
Abstract
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) La présente invention concerne des compositions et des procédés pour traiter une maladie chez un animal, cette maladie répondant à l'inhibition du polypeptide régulateur de la conductance transmembranaire de la mucoviscidose (CFTR), par administration à un mammifère le nécessitant d'une quantité efficace d'un composé défini ici (notamment les composés présentés dans les tableaux 1-2 ou représentés par les formules I-II) ou des compositions de ceux-ci, ce qui permet de traiter ainsi la maladie. La présente invention concerne en particulier un procédé de traitement de la diarrhée et de la polykystose rénale.
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