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1. WO2009131952 - COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES

Publication Number WO/2009/131952
Publication Date 29.10.2009
International Application No. PCT/US2009/041156
International Filing Date 20.04.2009
IPC
A01N 43/78 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
72having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms
74five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
781,3-Thiazoles; Hydrogenated 1,3-thiazoles
A61K 31/425 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
CPC
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
C07D 277/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 417/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • INSTITUTE FOR ONEWORLD HEALTH [US]/[US] (AllExceptUS)
  • DOYLE, Kevin, James [GB]/[GB] (UsOnly)
Inventors
  • DOYLE, Kevin, James
Agents
  • KONSKI, Antoinette, F.
Priority Data
61/046,77221.04.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS DE THIAZOLE
Abstract
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-V) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) La présente invention porte sur des compositions et des procédés pour traiter une maladie chez un animal, laquelle maladie est sensible à l'inhibition d'un polypeptide de régulateur de conductance transmembranaire de fibrose cystique fonctionnel (CFTR) par l'administration à un animal en ayant besoin d'une quantité efficace d'un composé défini ici (comprenant les composés établis dans les tableaux 1-2 ou englobés par les formules I-V) ou des compositions de celui-ci, ce qui permet ainsi de traiter la maladie. La présente invention porte en particulier sur un procédé consistant à traiter la diarrhée et la maladie polykystique des reins.
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