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1. (WO2009131951) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING ISOXAZOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/131951 International Application No.: PCT/US2009/041155
Publication Date: 29.10.2009 International Filing Date: 20.04.2009
IPC:
A01N 43/80 (2006.01) ,A61K 31/42 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
72
having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms
80
five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
Applicants:
JONES, Graham, Peter [GB/GB]; GB (UsOnly)
DOYLE, Kevin, James [GB/GB]; GB (UsOnly)
INSTITUTE FOR ONEWORLD HEALTH [US/US]; 50 California Street, Suite 500 San Francisco, CA 94111, US (AllExceptUS)
Inventors:
JONES, Graham, Peter; GB
DOYLE, Kevin, James; GB
Agent:
KONSKI, Antoinette, F.; US
Priority Data:
61/046,78121.04.2008US
Title (EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING ISOXAZOLE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS ISOXAZOLE
Abstract:
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) L'invention concerne des compositions et des procédés destinés à traiter une maladie chez un animal, ladite maladie réagissant à l'inhibition d'un polypeptide fonctionnel régulateur de la perméabilité transmembranaire de la fibrose cystique (CFTR). Ces procédés consistent à administrer, à un mammifère nécessitant un tel traitement, une quantité efficace d'un composé défini dans la description (y compris les composés définis dans les tableaux 1 et 2 ou inclus dans les formules I et II) ou de compositions de celui-ci, pour traiter ladite maladie. L'invention concerne en particulier un procédé de traitement de la diarrhée et d'une maladie polykystique des reins.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)