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1. WO2009131947 - COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE DERIVATIVES

Publication Number WO/2009/131947
Publication Date 29.10.2009
International Application No. PCT/US2009/041145
International Filing Date 20.04.2009
IPC
A01N 43/58 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48having rings with two nitrogen atoms as the only ring hetero atoms
581,2-Diazines; Hydrogenated 1,2-diazines
A01N 43/60 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48having rings with two nitrogen atoms as the only ring hetero atoms
601,4-Diazines; Hydrogenated 1,4-diazines
A61K 31/50 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
C07D 237/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
237Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02not condensed with other rings
06having three double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14Oxygen atoms
C07D 237/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
237Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02not condensed with other rings
06having three double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Nitrogen atoms
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • INSTITUTE FOR ONEWORLD HEALTH [US]/[US] (AllExceptUS)
  • RUSSELL, Michael, Geoffrey Neil [GB]/[GB] (UsOnly)
  • DOYLE, Kevin, James [GB]/[GB] (UsOnly)
  • PEACH, Joanne [GB]/[GB] (UsOnly)
Inventors
  • RUSSELL, Michael, Geoffrey Neil
  • DOYLE, Kevin, James
  • PEACH, Joanne
Agents
  • KONSKI, Antoinette, F.
Priority Data
61/046,75221.04.2008US
61/098,52819.09.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS À BASE DE DÉRIVÉS DE PYRAZIDINE
Abstract
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formula I) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) La présente invention concerne des compositions et procédés destinés au traitement d'une maladie affectant un animal, laquelle maladie répond favorablement au blocage du peptide fonctionnel régulateur de la conductance transmembranaire de la fibrose kystique ou "CFTR" (Cystic Fibrosis Transmembrane conductance Regulator) par administration, à un mammifère justifiant d'un tel traitement, d'une quantité suffisante d'un composé tel que défini dans la présente demande, y-compris les composés présentés dans le Tableau 1 ou pris en considération par la Formule (I), ou de compositions comprenant ces composés, ce qui permet de traiter la maladie. La présente invention concerne en particulier un procédé permettant de traiter la diarrhée et la polykystose rénale.
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