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1. (WO2009130471) ELECTROCHEMICAL ASSAY

Pub. No.:    WO/2009/130471    International Application No.:    PCT/GB2009/001047
Publication Date: Oct 29, 2009 International Filing Date: Apr 24, 2009
IPC: G01N 27/48
G01N 27/49
G01N 33/487
Applicants: OXTOX LIMITED
KAMPOURIS, Dimitrios, Konstantinos
KADARA, Rashid, Olukayoee
HUDDLESTON, Patrick, Robinson
BANKS, Craig, Edward
Inventors: KAMPOURIS, Dimitrios, Konstantinos
KADARA, Rashid, Olukayoee
HUDDLESTON, Patrick, Robinson
BANKS, Craig, Edward
Title: ELECTROCHEMICAL ASSAY
Abstract:
The invention provides an electrochemical assay for a phenol analyte in a body fluid sample wherein said sample, or fluid therefrom, is contacted with the working electrode of an electrode assembly comprising a working electrode, a counter-electrode, a voltage supply to said working and counter-electrodes and a current meter for determining the current between said working and counter-electrodes, and wherein a first compound capable of reversible oxidation and reduction is disposed at said working electrode, said first compound being capable in either an oxidized or a reduced form of binding to said phenol analyte, characterized in that said first compound in its oxidized or reduced form comprises a group of structure I R1 -NH-C*- (C*-C*)n-C*-QR' (I) (where n is 0 or 1; Q is 0, S, NH or NR'; C*- (C*-C*)n-C* is a two or four carbon string in a conjugated delocalised electron system optionally substituted by a group comprising R; R is an electron-donating or withdrawing substituent; and R' is H or a group R, at least one group R' being a group R).