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1. WO2009130189 - 2'-O,3'-N-BRIDGED MACROLIDES

Publication Number WO/2009/130189
Publication Date 29.10.2009
International Application No. PCT/EP2009/054685
International Filing Date 20.04.2009
IPC
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
A61K 31/7048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
CPC
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • BUKVIC-KRAJACIC, Mirjana [HR]/[HR] (UsOnly)
  • HUTINEC, Antun [HR]/[HR] (UsOnly)
  • KRAGOL, Goran [HR]/[HR] (UsOnly)
  • KUJUNDZIC, Nedjeljko [HR]/[HR] (UsOnly)
  • MARUSIC-ISTUK, Zorica [HR]/[HR] (UsOnly)
Inventors
  • BUKVIC-KRAJACIC, Mirjana
  • HUTINEC, Antun
  • KRAGOL, Goran
  • KUJUNDZIC, Nedjeljko
  • MARUSIC-ISTUK, Zorica
Agents
  • CRAWLEY, Karen
Priority Data
61/047,21623.04.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 2'-O,3'-N-BRIDGED MACROLIDES
(FR) MACROLIDES 2'-O,3'-N-PONTÉS
Abstract
(EN) Novel 2 ' -O, 3 ' -/V-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2 ' -O, 3 ' -/V-bridged 14- membered macrolides and to 2 ' - O, 3 ' -/V-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.
(FR) L'invention porte sur de nouveaux macrolides 2'-O,3'-N-pontés utiles dans le traitement de maladies inflammatoires. Plus particulièrement, l'invention porte sur des macrolides à 14 chaînons 2'-O,3'-N-ponté et sur des macrolides azalides à 15 chaînons 2'-O,3'-N-pontés utiles dans le traitement de maladies inflammatoires dominées par les neutrophiles résultant d'une infiltration neutrophile et/ou de maladies associées à une fonctionnalité cellulaire modifiée de neutrophiles. L'invention porte également sur des intermédiaires pour la fabrication des macrolides, sur leurs procédés de fabrication, sur leur utilisation comme agents thérapeutiques et sur des sels de ceux-ci.
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