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1. (WO2009130189) 2'-O,3'-N-BRIDGED MACROLIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/130189 International Application No.: PCT/EP2009/054685
Publication Date: 29.10.2009 International Filing Date: 20.04.2009
IPC:
C07H 17/08 (2006.01) ,A61K 31/7048 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
08
Hetero rings containing eight or more ring members, e.g. erythromycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
Applicants:
BUKVIC-KRAJACIC, Mirjana [HR/HR]; HR (UsOnly)
HUTINEC, Antun [HR/HR]; HR (UsOnly)
KRAGOL, Goran [HR/HR]; HR (UsOnly)
KUJUNDZIC, Nedjeljko [HR/HR]; HR (UsOnly)
MARUSIC-ISTUK, Zorica [HR/HR]; HR (UsOnly)
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
Inventors:
BUKVIC-KRAJACIC, Mirjana; HR
HUTINEC, Antun; HR
KRAGOL, Goran; HR
KUJUNDZIC, Nedjeljko; HR
MARUSIC-ISTUK, Zorica; HR
Agent:
CRAWLEY, Karen; GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
61/047,21623.04.2008US
Title (EN) 2'-O,3'-N-BRIDGED MACROLIDES
(FR) MACROLIDES 2'-O,3'-N-PONTÉS
Abstract:
(EN) Novel 2 ' -O, 3 ' -/V-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2 ' -O, 3 ' -/V-bridged 14- membered macrolides and to 2 ' - O, 3 ' -/V-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.
(FR) L'invention porte sur de nouveaux macrolides 2'-O,3'-N-pontés utiles dans le traitement de maladies inflammatoires. Plus particulièrement, l'invention porte sur des macrolides à 14 chaînons 2'-O,3'-N-ponté et sur des macrolides azalides à 15 chaînons 2'-O,3'-N-pontés utiles dans le traitement de maladies inflammatoires dominées par les neutrophiles résultant d'une infiltration neutrophile et/ou de maladies associées à une fonctionnalité cellulaire modifiée de neutrophiles. L'invention porte également sur des intermédiaires pour la fabrication des macrolides, sur leurs procédés de fabrication, sur leur utilisation comme agents thérapeutiques et sur des sels de ceux-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)