WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009129696) A KIND OF RECEPTOR SIGNALING TRANSOLUCTION POSITIVE MODULATORS, PREPARATION METHODS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/129696    International Application No.:    PCT/CN2009/000440
Publication Date: 29.10.2009 International Filing Date: 27.04.2009
IPC:
C07D 277/54 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 417/12 (2006.01), A61K 31/426 (2006.01), A61K 31/427 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01), A61P 5/48 (2006.01), A61P 9/00 (2006.01), A61P 25/28 (2006.01), A61P 25/00 (2006.01)
Applicants: THE NATIONAL CENTER FOR DRUG SCREENING [CN/CN]; 189 Guo Shou Jing Road Zhangjiang High-Tech Park Pudong New District Shanghai 201203 (CN) (For All Designated States Except US).
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 555 Zhu Chong Zhi Road Zhangjiang, Pudong New District Shanghai 201203 (CN) (For All Designated States Except US).
WANG, Mingwei [CN/CN]; (CN) (For US Only).
YUAN, Yunyun [CN/CN]; (CN) (For US Only).
ZHOU, Ling [CN/CN]; (CN) (For US Only).
YOUNG, Andrew, A. [US/CN]; (CN) (For US Only).
ZHANG, Ao [CN/CN]; (CN) (For US Only).
GAO, Lindong [CN/CN]; (CN) (For US Only).
SU, Haoran [CN/CN]; (CN) (For US Only).
WU, Qianqian [CN/CN]; (CN) (For US Only).
WANG, Jia [CN/CN]; (CN) (For US Only).
WANG, Ju [CN/CN]; (CN) (For US Only)
Inventors: WANG, Mingwei; (CN).
YUAN, Yunyun; (CN).
ZHOU, Ling; (CN).
YOUNG, Andrew, A.; (CN).
ZHANG, Ao; (CN).
GAO, Lindong; (CN).
SU, Haoran; (CN).
WU, Qianqian; (CN).
WANG, Jia; (CN).
WANG, Ju; (CN)
Agent: JEEKAI & PARTNERS; Suite 602 , Jinyu Tower, A129 West Xuan Wu Men Street, Beijing 100031 (CN)
Priority Data:
200810036610.1 25.04.2008 CN
Title (EN) A KIND OF RECEPTOR SIGNALING TRANSOLUCTION POSITIVE MODULATORS, PREPARATION METHODS AND USES THEREOF
(FR) TYPE DE MODULATEURS POSITIFS DE TRANSDUCTION DE SIGNALISATION DE RÉCEPTEUR, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS DE CEUX-CI
(ZH) 一类受体信号转导增效剂,其制备方法和用途
Abstract: front page image
(EN)A kind of substituted five-membered heterocyclic compounds represented by the following formula I, pharmaceutically acceptable salts, esters, salvates, metal complex or prodrug with the same biological activity thereof. The uses of those compounds as GLP-1 receptor signaling transoluction positive modulators, and in the treatment and/or prophylaxis of diseases relating to metabolic diseases (including but not limited to type-2 diabetes, insulin resistance and obesity etc.), cardiovascular disease and neuro degenerative diseases(such as Alzheimer's Disease,AD, also said Alzheimer's dememtia).
(FR)La présente invention concerne un type de composés hétérocycliques à cinq chaînons substitués représentés par la formule I suivante, des sels, esters, solvates, complexes métalliques ou promédicaments pharmaceutiquement acceptables ayant la même activité biologique de ceux-ci. La présente invention concerne en outre les utilisations de ces composés en tant que modulateurs positifs de transduction de signalisation de récepteur GLP-1, et dans le traitement et/ou la prophylaxie de maladies associées à des maladies métaboliques (comprenant, mais sans y être limitées, le diabète de type 2, l’insulinorésistance et l’obésité, etc.), des maladies cardiovasculaires et des maladies neurodégénératives (telles que la maladie d’Alzheimer, AD, également appelée démence d’Alzheimer).
(ZH)本发明提供由以下通式表示的一类取代五元杂环化合物及其药学上可以接受的盐、酯、溶剂化物、金属配 合物、或者具有相同生物活性的前药。本发明还提供了该类化合物作为一类胰高血糖样肽-1受体(GLP-1R )信号转导增效剂(Positive modulator)的用途以及在预防和/或治疗与代谢性疾病(包括但不局限于2型糖尿病、胰岛素抵抗和肥胖症 等)、心血管疾病和神经退行性疾病【如“阿尔茨海默病”(Alzheimer's Disease, AD),又称早老性痴呆(Alzheimer's dementia)】等中的应用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)