WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009129191) POLYMORPHS OF HYDROCHLORIDE SALT O5-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PYRIDO[2,3-B] INDOLE-7-CARBOXAMIDEAND METHODS OF USE THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/129191    International Application No.:    PCT/US2009/040390
Publication Date: 22.10.2009 International Filing Date: 13.04.2009
IPC:
C07D 471/04 (2006.01), A61P 9/00 (2006.01), A61P 35/00 (2006.01), A61K 31/437 (2006.01)
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi , Osaka 541-0045 (JP) (For All Designated States Except US).
GRAHAM, Lauren [US/US]; (US) (For US Only).
ISBESTER, Paul [US/US]; (US) (For US Only).
LAPINA, Olga, V. [US/US]; (US) (For US Only).
MOBELE, Bingidimi, I. [US/US]; (US) (For US Only).
PALMER, Grant, J. [US/US]; (US) (For US Only).
REINEKE, Karl [US/US]; (US) (For US Only).
SALSBURY, Jonathon S. [US/US]; (US) (For US Only).
ULYSSE, Luckner [US/US]; (US) (For US Only)
Inventors: GRAHAM, Lauren; (US).
ISBESTER, Paul; (US).
LAPINA, Olga, V.; (US).
MOBELE, Bingidimi, I.; (US).
PALMER, Grant, J.; (US).
REINEKE, Karl; (US).
SALSBURY, Jonathon S.; (US).
ULYSSE, Luckner; (US)
Agent: SMITH, Amy, C.; (US)
Priority Data:
61/045,523 16.04.2008 US
Title (EN) POLYMORPHS OF HYDROCHLORIDE SALT O5-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PYRIDO[2,3-B] INDOLE-7-CARBOXAMIDEAND METHODS OF USE THEREFOR
(FR) POLYMORPHES DE SEL CHLORHYDRATE DE 5-(3-(ÉTHYLSULFONYL)PHÉNYL)-3,8-DIMÉTHYL-N-(1-MÉTHYLPIPÉRIDIN-4-YL)-9H-PYRIDO[2,3-B]INDOLE-7-CARBOXAMIDE ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1 -methyIpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: and compositions thereof, wherein the Compound 1 is present in one or more polymorphic forms. Also provided are novel methods for the preparation of the polymorphs of Compound 1, and kits and articles of manufacture of the compositions, and methods of using the compositions to treat a disease state for which a kinase possesses activity that contributes to the pathology selected from the group consisting of cancer, dementia related diseases and arthritis.
(FR)L'invention porte sur des formes polymorphes du sel chlorhydrate de 5-(3-(éthylsulfonyl)phényl)-3,8-diméthyl-N-(1-méthylpipéridin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide (appelé ici Composé 1) qui a la formule : et sur des compositions à la base de celui-ci, le Composé 1 étant présent sous une ou plusieurs formes polymorphes. L'invention porte également sur de nouveaux procédés pour la préparation des polymorphes du Composé 1, et sur des coffrets et articles de fabrication des compositions, et sur des procédés d'utilisation des compositions pour traiter un état de maladie pour lequel une kinase possède une activité qui contribue à la pathologie choisie dans le groupe constitué par le cancer, les maladies liées à la démence et l'arthrite.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)