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1. (WO2009129138) METHOD FOR WATER-FAT SEPARATION AND T2* ESTIMATION IN AN MRI SYSTEM EMPLOYING MULTIPLE FAT SPECTRAL PEAKS AND FAT SPECTRUM SELF-CALIBRATION

Pub. No.:    WO/2009/129138    International Application No.:    PCT/US2009/040185
Publication Date: Oct 22, 2009 International Filing Date: Apr 10, 2009
IPC: G01R 33/54
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION
YU, Huanzhou
REEDER, Scott, B.
Inventors: YU, Huanzhou
REEDER, Scott, B.
Title: METHOD FOR WATER-FAT SEPARATION AND T2* ESTIMATION IN AN MRI SYSTEM EMPLOYING MULTIPLE FAT SPECTRAL PEAKS AND FAT SPECTRUM SELF-CALIBRATION
Abstract:
NMR signal contributions from water and fat are separated using a model of the fat resonant frequency spectrum that has multiple resonant peaks. The relative frequencies of the multiple fat spectrum peaks are known a priori and their relative amplitudes are determined using a self-calibration process. With the determined relative amplitudes of the fat spectrum peaks, acquired NMR signals are modeled. Using this model and NMR signal data acquired at a plurality of echo times (TE), the signal contribution from multiple fat spectrum peaks is separated from the acquired NMR signal data. A combined image is alternatively produced from weighted contributions of the separated water and fat images. Additionally, a more accurate estimation of the apparent relaxation time and rate (T2* and R2*, respectively) is alternatively performed.