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1. (WO2009129018) ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/129018    International Application No.:    PCT/US2009/037637
Publication Date: 22.10.2009 International Filing Date: 19.03.2009
IPC:
G01N 33/68 (2006.01), C07K 14/00 (2006.01)
Applicants: MOMENTA PHARMACEUTICALS, INC. [US/US]; 675 West Kendall Street Cambridge, MA 02142 (US) (For All Designated States Except US).
ZHU, Xiangping [US/US]; (US) (For US Only).
SHRIVER, Zachary [US/US]; (US) (For US Only).
JIANG, Yanjie [CN/US]; (US) (For US Only).
BAUER, Corinne [FR/US]; (US) (For US Only).
ANDERSON, James, Eric [US/US]; (US) (For US Only).
AHERN, Peter, James [US/US]; (US) (For US Only)
Inventors: ZHU, Xiangping; (US).
SHRIVER, Zachary; (US).
JIANG, Yanjie; (US).
BAUER, Corinne; (US).
ANDERSON, James, Eric; (US).
AHERN, Peter, James; (US)
Agent: MEIKLEJOHN, Anita, L.; (US)
Priority Data:
61/045,465 16.04.2008 US
Title (EN) ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS
(FR) ANALYSE DE COMPOSITIONS COPOLYMÈRES D'ACIDES AMINÉS
Abstract: front page image
(EN)Methods for analyzing, selecting characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, is some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard/ In some cases the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.
(FR)L'invention porte sur des procédés destinés à l'analyse, la sélection, la caractérisation ou la classification de compositions d'un copolymère, par exemple l'acétate de glatiramère. Les procédés permettent d'analyser le pyroglutamate dans la composition et, dans certains des procédés, de comparer la quantité de pyroglutamate présente dans une composition à un étalon de référence. Dans certains cas, les procédés permettent le traitement du copolymère avec de la pyroglutamate-aminopeptidase pour cliver les résidus de pyroglutamate N-terminaux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)