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1. (WO2009128919) DEUTERIUM BEARING ANALOGS OF ANASTROZOLE AS AROMATASE INHIBITORS FOR THE TREATMENT OF BREAST CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/128919    International Application No.:    PCT/US2009/002354
Publication Date: 22.10.2009 International Filing Date: 15.04.2009
IPC:
C07D 249/08 (2006.01), A61K 31/4196 (2006.01), A61P 35/00 (2006.01)
Applicants: CONCERT PHARMACEUTICALS, INC. [US/US]; 99 Hayden Avenue, Suite 500 Lexington, MA 02421 (US) (For All Designated States Except US).
HARBESON, Scott, L. [US/US]; (US) (For US Only)
Inventors: HARBESON, Scott, L.; (US)
Agent: ABELLEIRA, Susan M.; (US)
Priority Data:
61/044,998 15.04.2008 US
Title (EN) DEUTERIUM BEARING ANALOGS OF ANASTROZOLE AS AROMATASE INHIBITORS FOR THE TREATMENT OF BREAST CANCER
(FR) ANALOGUES D'ANASTROZOLE PORTANT DU DEUTÉRIUM EN TANT QU'INHIBITEURS D'AROMATASE POUR LE TRAITEMENT DU CANCER DU SEIN
Abstract: front page image
(EN)This invention relates to novel, substituted aralkyl heterocyclic compounds according to formula I, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering aromatase inhibitors. Formula (I), or a pharmaceutically acceptable salt thereof, wherein: each R1 is independently selected from CH3, CH2D, CHD2 or CD3; each R2 is independently selected from CH3, CH2D, CHD2 or CD3; each Y is independently selected from H or D; and when each R variable is CH3, at least one Y is D.
(FR)Cette invention porte sur de nouveaux composés hétérocycliques aralkyles substitués selon la formule I, sur leurs dérivés, sur leurs sels pharmaceutiquement acceptables. L'invention porte également sur des compositions comprenant un composé de cette invention et sur l'utilisation de telles compositions dans des procédés de traitement de maladies et d'états qui sont traités de façon utile par l'administration d'inhibiteurs d'aromatase. Les composés de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, formule dans laquelle : les R1 sont chacun indépendamment choisis parmi CH3, CH2D, CHD2 ou CD3; les R2 sont chacun indépendamment choisis parmi CH3, CH2D, CHD2 ou CD3; les Y sont chacun indépendamment choisis parmi H ou D; et lorsque chaque variable R est CH3, au moins un Y est D.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)