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1. (WO2009128558) ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

Pub. No.:    WO/2009/128558    International Application No.:    PCT/JP2009/057946
Publication Date: Oct 22, 2009 International Filing Date: Apr 15, 2009
IPC: C07D 333/56
A61K 31/381
A61K 31/423
A61P 1/04
A61P 1/16
A61P 1/18
A61P 3/04
A61P 3/06
A61P 3/10
A61P 7/02
A61P 9/00
A61P 9/04
A61P 9/10
A61P 9/12
A61P 11/00
A61P 11/06
A61P 13/08
A61P 15/00
A61P 17/00
A61P 17/06
A61P 17/10
A61P 17/14
A61P 19/02
A61P 21/04
A61P 25/00
A61P 25/28
A61P 29/00
A61P 35/00
A61P 43/00
C07D 333/58
C07D 413/06
Applicants: NIPPON CHEMIPHAR CO., LTD.
日本ケミファ株式会社
SAKUMA, Shogo
佐久間詔悟
TAKAHASHI, Rie
高橋理恵
NAKAMURA, Hideki
中村英生
Inventors: SAKUMA, Shogo
佐久間詔悟
TAKAHASHI, Rie
高橋理恵
NAKAMURA, Hideki
中村英生
Title: ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR
Abstract:
Disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof, which can be used as an activator for a PPAR. (In the formula, R1 and R2 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and substituted by a halogen atom, or the like; R3, R4, R5 and R6 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like; X represents a sulfur atom or the like; Y represents an oxygen atom, a bond or the like; p represents a number of 0 or 1; A represents an oxygen atom, CH2, N-NH2 or the like; B represents a benzene ring which may have a substituent when p is 1, or B represents a fused ring selected from a benzisoxazole ring which may have a substituent and others when p is 0; m represents an integer of 1 to 4; and n represents an integer of 0 to 5.)