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1. (WO2009128520) HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/128520    International Application No.:    PCT/JP2009/057706
Publication Date: 22.10.2009 International Filing Date: 16.04.2009
IPC:
C07D 487/04 (2006.01), A61K 31/5025 (2006.01), A61K 31/506 (2006.01), A61K 31/5377 (2006.01), A61K 31/55 (2006.01), A61P 9/00 (2006.01), A61P 9/10 (2006.01), A61P 11/02 (2006.01), A61P 17/04 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), A61P 31/00 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01), A61P 43/00 (2006.01)
Applicants: Shionogi & Co., Ltd. [JP/JP]; 1-8, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP) (For All Designated States Except US).
TANIYAMA Daisuke [JP/JP]; (JP) (For US Only).
KANO Kazuya [JP/JP]; (JP) (For US Only).
OKAMOTO Kazuya [JP/JP]; (JP) (For US Only).
FUJIOKA Masahiko [JP/JP]; (JP) (For US Only).
MITSUOKA Yasunori [JP/JP]; (JP) (For US Only)
Inventors: TANIYAMA Daisuke; (JP).
KANO Kazuya; (JP).
OKAMOTO Kazuya; (JP).
FUJIOKA Masahiko; (JP).
MITSUOKA Yasunori; (JP)
Agent: YAMAMOTO Shusaku; Fifteenth Floor, Crystal Tower, 2-27, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5406015 (JP)
Priority Data:
2008-109548 18.04.2008 JP
Title (EN) HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K
(FR) COMPOSÉ HÉTÉROCYCLIQUE PRÉSENTANT UNE ACTIVITÉ INHIBITRICE SUR P13K
(JA) P13K阻害活性を有する複素環化合物
Abstract: front page image
(EN)Disclosed is a compound or a pharmaceutically acceptable salt thereof which can inhibit the activity of P13K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration and metabolism of cells and is therefore useful for the prevention/treatment of diseases including inflammatory diseases, arteriosclerosis, vascular/cardiovascular diseases, cancer/tumors, immune system diseases, cell proliferative diseases and infectious diseases. Specifically disclosed is a substituted 2-amino-5,6- nitrogenated fused ring compound or a pharmaceutically acceptable salt thereof.
(FR)L’invention concerne un composé ou un de ses sels pharmaceutiquement acceptables, qui peut inhiber l’activité de P13K pour réguler de nombreux processus biologiques, y compris la croissance, la différenciation, la survie, la prolifération, la migration et le métabolisme de cellules, et qui est par conséquent utile pour la prévention/le traitement de maladies, notamment de maladies inflammatoires, de l’artériosclérose, de maladies vasculaires/cardiovasculaires, de cancers/tumeurs, de maladies du système immunitaire, de maladies de la prolifération cellulaire et de maladies infectieuses. L’invention concerne spécifiquement un composé à cycle fusionné 2-amino-5,6-azoté substitué ou un de ses sels pharmaceutiquement acceptables.
(JA)本発明の目的は、PI3Kの作用を阻害し、細胞の成長、分化、生存、増殖、遊走および代謝等、多数の生物学的プロセスを制御することによって、炎症性疾患、動脈硬化症、血管系・循環器系疾患、がん・腫瘍、免疫系疾患、細胞増殖性疾患、感染症等の疾患の予防・治療のために有用な化合物またはその薬学的に許容される塩を提供することである。本明細書に示される置換型2-アミノ-5,6-含窒素縮合環化合物またはその薬学的に許容される塩を提供することによって上記目的が達成された。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)