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1. (WO2009127705) NOVEL THERAPEUTICAL TOOLS AND METHODS FOR TREATING BLINDNESS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/127705    International Application No.:    PCT/EP2009/054562
Publication Date: 22.10.2009 International Filing Date: 16.04.2009
IPC:
A61K 48/00 (2006.01), C07K 14/215 (2006.01), A61K 38/17 (2006.01)
Applicants: NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH [CH/CH]; Maulbeerstrasse 66 CH-4058 Basel (CH) (For All Designated States Except US).
BALYA, David [HU/CH]; (CH) (For US Only).
BUSSKAMP, Volker [DE/CH]; (CH) (For US Only).
LAGALI, Pamela [CA/CH]; (CH) (For US Only).
ROSKA, Botond [HU/CH]; (CH) (For US Only)
Inventors: BALYA, David; (CH).
BUSSKAMP, Volker; (CH).
LAGALI, Pamela; (CH).
ROSKA, Botond; (CH)
Agent: FAVRE, Nicolas; (CH)
Priority Data:
08154828.1 18.04.2008 EP
08155942.9 09.05.2008 EP
Title (EN) NOVEL THERAPEUTICAL TOOLS AND METHODS FOR TREATING BLINDNESS
(FR) NOUVEAUX OUTILS ET PROCÉDÉS THÉRAPEUTIQUES POUR LE TRAITEMENT DE LA CÉCITÉ
Abstract: front page image
(EN)The present inventions relates to the use of an isolated nucleic acid molecule comprising a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence complementary to said nucleotide sequence, for treating or ameliorating blindness. The light-gated ion channel or pump gene can be a halorhodopsin gene.
(FR)La présente invention concerne l’utilisation d’une molécule d’acide nucléique isolée comprenant une séquence nucléotidique codant pour un gène de canal ionique ou de pompe contrôlé par une lumière hyperpolarisante à partir d’un archéon ou pour un fragment actif à la lumière dudit gène ou la séquence nucléotidique complémentaire de ladite séquence nucléotidique, pour le traitement ou l’amélioration d’une cécité. Le gène de canal ionique ou de pompe contrôlé par la lumière peut être un gène d’halogénorhodopsine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)