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1. (WO2009127048) METHOD OF TREATING DEMYELINATING DIESASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/127048    International Application No.:    PCT/CA2009/000473
Publication Date: 22.10.2009 International Filing Date: 17.04.2009
IPC:
C12N 9/78 (2006.01), A61K 31/155 (2006.01), A61K 31/16 (2006.01), A61K 31/714 (2006.01), A61P 25/28 (2006.01), C07K 7/08 (2006.01), G01N 33/53 (2006.01)
Applicants: THE HOSPITAL FOR SICK CHILDREN [CA/CA]; 555 University Avenue Toronto , Ontario M5G 1X8 (CA) (For All Designated States Except US).
MASTRONARDI, Fabrizio [CA/CA]; (CA) (For US Only).
MOSCARELLO, Mario A. [CA/CA]; (CA) (For US Only).
WOOD, Denise [CA/CA]; (CA) (For US Only)
Inventors: MASTRONARDI, Fabrizio; (CA).
MOSCARELLO, Mario A.; (CA).
WOOD, Denise; (CA)
Agent: GOWLING LAFLEUR HENDERSON LLP; Suite 1020 50 Queen Street North P.O. Box 2248 Kitchener , Ontario N2H 6M2 (CA)
Priority Data:
61/071,253 18.04.2008 US
Title (EN) METHOD OF TREATING DEMYELINATING DIESASE
(FR) PROCÉDÉ DE TRAITEMENT D'UNE MALADIE DE DÉMYÉLINISATION
Abstract: front page image
(EN)A method of inhibiting Peptidyl Argininedeiminase (PAD) in a mammal is provided wherein said method comprises the step of administering 2-haloacetamidine to a mammal. The method is useful to treat a demyelinating disease in mammals such as multiple sclerosis, as well as other diseases in which hyper-citrullination is a factor. Pharmaceutical compositions useful to treat said disease are also provided, as well as a method of screening for PAD inhibitors.
(FR)L'invention porte sur un procédé d'inhibition de la peptidyl-arginine désiminase (PAD) chez un mammifère, ledit procédé comprenant l'étape consistant à administrer de la 2-haloacétamidine à un mammifère. Le procédé est utile pour traiter une maladie de démyélinisation chez des mammifères telle que la sclérose en plaques, ainsi que d'autres maladies dans lesquelles l'hypercitrullination est un facteur. L'invention porte également sur des compositions pharmaceutiques utiles pour traiter ladite maladie, ainsi que sur un procédé de criblage d'inhibiteurs de PAD.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)