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1. (WO2009126966) GENETIC MARKERS INDICATING BIOLOGICAL RESPONSE TO A PLK1 KINASE INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/126966    International Application No.:    PCT/US2009/040392
Publication Date: 15.10.2009 International Filing Date: 13.04.2009
IPC:
G01N 33/574 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 (US) (For All Designated States Except US).
GRAY, Joe, W. [US/US]; (US) (For US Only).
DAS, Debopriya [IN/US]; (US) (For US Only).
KUO, Wen-lin [US/US]; (US) (For US Only).
HU, Zhi [CN/US]; (US) (For US Only).
WANG, Nicholas, J. [US/US]; (US) (For US Only).
FEILER, Heidi, S. [US/US]; (US) (For US Only).
SPELLMAN, Paul, T. [US/US]; (US) (For US Only)
Inventors: GRAY, Joe, W.; (US).
DAS, Debopriya; (US).
KUO, Wen-lin; (US).
HU, Zhi; (US).
WANG, Nicholas, J.; (US).
FEILER, Heidi, S.; (US).
SPELLMAN, Paul, T.; (US)
Agent: WONG, Michelle, Chew; (US)
Priority Data:
61/044,437 11.04.2008 US
Title (EN) GENETIC MARKERS INDICATING BIOLOGICAL RESPONSE TO A PLK1 KINASE INHIBITOR
(FR) MARQUEURS GÉNÉTIQUES INDIQUANT UNE RÉPONSE BIOLOGIQUE À UN INHIBITEUR DE LA PLK1 KINASE
Abstract: front page image
(EN)The invention provides for a method for identifying a cancer patient, such as a breast cancer patient, suitable for treatment with a Polo-like kinase inhibitor, such as GSK461364, comprising detecting modulated expression of PLKl and one or more of a set of predictive biomarkers, or protein encoded thereof.
(FR)L’invention propose un procédé d’identification d’un patient cancéreux, comme un patient avec cancer du sein, approprié pour le traitement avec un inhibiteur de kinase de type Polo, comme GSK461364, comprenant la détection de l’expression modulée de la PLK1 et d’un ou plusieurs biomarqueurs d’un ensemble de biomarqueurs prédictifs, ou de la protéine codée par ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)