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1. (WO2009126863) PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/126863    International Application No.:    PCT/US2009/040165
Publication Date: 15.10.2009 International Filing Date: 10.04.2009
IPC:
C07D 403/14 (2006.01), C07D 403/06 (2006.01), C07D 213/06 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 Dna Way South San Francisco, CA 94080 (US) (For All Designated States Except US).
CURIS, INC. [US/US]; 45 Moulton Street Cambridge, MA 02138 (US) (For All Designated States Except US).
GUNZNER, Janet, L. [US/US]; (US) (For US Only).
SUTHERLIN, Daniel, P. [US/US]; (US) (For US Only).
STANLEY, Mark, S. [US/US]; (US) (For US Only).
BAO, Liang [CN/US]; (US) (For US Only).
CASTANEDO, Georgette [US/US]; (US) (For US Only).
LALONDE, Rebecca, L. [US/US]; (US) (For US Only).
WANG, Shumei [CA/US]; (US) (For US Only).
REYNOLDS, Mark, E. [US/US]; (US) (For US Only).
SAVAGE, Scott, J. [US/US]; (US) (For US Only).
MALESKY, Kimberly [US/US]; (US) (For US Only).
DINA, Michael, S. [US/US]; (US) (For US Only)
Inventors: GUNZNER, Janet, L.; (US).
SUTHERLIN, Daniel, P.; (US).
STANLEY, Mark, S.; (US).
BAO, Liang; (US).
CASTANEDO, Georgette; (US).
LALONDE, Rebecca, L.; (US).
WANG, Shumei; (US).
REYNOLDS, Mark, E.; (US).
SAVAGE, Scott, J.; (US).
MALESKY, Kimberly; (US).
DINA, Michael, S.; (US)
Agent: EVANS, David, W.; (US)
Priority Data:
61/044,451 11.04.2008 US
Title (EN) PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
(FR) INHIBITEURS PYRIDILES DE SIGNALISATION HEDGEHOG
Abstract: front page image
(EN)The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.
(FR)L'invention concerne de nouveaux inhibiteurs de signalisation Hedgehog qui sont utiles en tant qu'agent thérapeutique pour traiter des malignites, les composés étant de la formule générale (I) : dans laquelle, A, X, Y, R1, R2, R3, R4, m et n sont tels que décrits dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)