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1. (WO2009126835) MAGNETIC NANOPARTICLE AND METHOD FOR IMAGING T CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/126835    International Application No.:    PCT/US2009/040114
Publication Date: 15.10.2009 International Filing Date: 09.04.2009
IPC:
A61K 9/16 (2006.01), B82B 3/00 (2006.01), A61P 37/02 (2006.01), A61K 31/70 (2006.01), G01N 33/574 (2006.01), A61K 49/10 (2006.01)
Applicants: UNIVERSITY OF WASHINGTON TECHTRANSFER INVENTION LICENSING [US/US]; 4311-11th Avenue NE, Suite 500 Seattle, WA 98105-4608 (US) (For All Designated States Except US).
FRED HUTCHINSON CANCER RESEARCH CENTER [US/US]; 1100 Fairview Avenue North, J5-110, Seattle, WA 98177 (US) (For All Designated States Except US).
ZHANG, Miqin [US/US]; (US) (For US Only).
YEE, Cassian [CA/US]; (US) (For US Only).
GUNN, Jonathan, Whitney [US/US]; (US) (For US Only)
Inventors: ZHANG, Miqin; (US).
YEE, Cassian; (US).
GUNN, Jonathan, Whitney; (US)
Agent: KALE, Tamara, A.; Christensen O'Connor Johnson Kindness PLLC 1420 Fifth Avenue, Suite 2800 Seattle, WA 98101 (US)
Priority Data:
61/043596 09.04.2008 US
Title (EN) MAGNETIC NANOPARTICLE AND METHOD FOR IMAGING T CELLS
(FR) NANOPARTICULES MAGNÉTIQUES, ET PROCÉDÉ D'IMAGERIE DE CELLULES T
Abstract: front page image
(EN)The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (MHC) monomer. The antigenic peptide-MHC monomer may then be recognized by a T cell receptor. These nanoparticles may further comprise a signal-generating label, such as a fluorophore. Methods employing nanoparticles of the present invention may involve magnetic resonance imaging and/or fluorescence detection, such that cell imaging and localization are performed.
(FR)La présente invention concerne des nanoparticules ayant un noyau comprenant un matériau magnétique, et ayant une surface, la surface pouvant être liée de manière fonctionnelle à un monomère de complexe majeur d'histocompatibilité (MHC) peptide antigénique. Le monomère de MHC-peptide antigénique peut ensuite être reconnu par un récepteur de lymphocytes T. Ces nanoparticules peuvent en outre comprendre une étiquette génératrice de signal, telle qu'un fluorophore. Des procédés utilisant des nanoparticules de l'invention peuvent impliquer une imagerie par résonance magnétique et/ou une détection par fluorescence, de telle sorte qu'une imagerie et une localisation de cellules sont effectuées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)