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1. (WO2009126822) METHODS OF REGULATING ACTIN CYTOSKELETAL REARRANGEMENT AND INTERCELLULAR GAP FORMATION

Pub. No.:    WO/2009/126822    International Application No.:    PCT/US2009/040098
Publication Date: Oct 15, 2009 International Filing Date: Apr 9, 2009
IPC: A61K 31/7028
A61K 31/7008
A61P 7/06
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
EGAN, Thomas, Michael
Inventors: EGAN, Thomas, Michael
Title: METHODS OF REGULATING ACTIN CYTOSKELETAL REARRANGEMENT AND INTERCELLULAR GAP FORMATION
Abstract:
Methods are described for preventing or reducing cytoskeletal rearrangement and intercellular gap formation by contacting cells with an aminoalkyl glucosaminide phosphate. In particular, the disclosed methods can be used to prevent or reduce actin cytoskeletal rearrangement and/or intracellular gap formation related to ischemic or ischemia-reperfusion events and to prevent or alleviate diseases or conditions related to increased actin cytoskeletal rearrangement.