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1. (WO2009126584) GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/126584    International Application No.:    PCT/US2009/039678
Publication Date: 15.10.2009 International Filing Date: 06.04.2009
IPC:
A61K 31/517 (2006.01), A61K 31/519 (2006.01), A61K 31/527 (2006.01), C07D 239/70 (2006.01), C07D 401/12 (2006.01), C07D 471/04 (2006.01), C07D 471/10 (2006.01), C07D 487/04 (2006.01), C07D 491/052 (2006.01), C07D 491/20 (2006.01), C07D 491/22 (2006.01), C07D 491/107 (2006.01), C07D 491/147 (2006.01), A61P 35/00 (2006.01)
Applicants: AMGEN INC. [US/US]; One Amgen Center Drive Thousand Oaks, CA 91320-1799 (US) (For All Designated States Except US).
CONNORS, Richard, V. [CA/US]; (US) (For US Only).
DAI, Kang [US/US]; (US) (For US Only).
EKSTEROWICZ, John [US/US]; (US) (For US Only).
FAN, Pingchen [US/US]; (US) (For US Only).
FISHER, Benjamin [CA/US]; (US) (For US Only).
FU, Jiasheng [CA/US]; (US) (For US Only).
LI, Kexue [CN/US]; (US) (For US Only).
LI, Zhihong [US/US]; (US) (For US Only).
MCGEE, Lawrence, R. [US/US]; (US) (For US Only).
SHARMA, Rajiv [US/US]; (US) (For US Only).
WANG, Xiaodong [US/US]; (US) (For US Only)
Inventors: CONNORS, Richard, V.; (US).
DAI, Kang; (US).
EKSTEROWICZ, John; (US).
FAN, Pingchen; (US).
FISHER, Benjamin; (US).
FU, Jiasheng; (US).
LI, Kexue; (US).
LI, Zhihong; (US).
MCGEE, Lawrence, R.; (US).
SHARMA, Rajiv; (US).
WANG, Xiaodong; (US)
Agent: HERMENAU, Ronald, S.; AMGEN INC. 1120 Veterans Boulevard South San Francisco, CA 94080 (US)
Priority Data:
61/123,279 07.04.2008 US
Title (EN) GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS
(FR) PYRIDINES/PYRIMIDINES AMINO SPIROCYCLIQUES ET DISUBSTITUÉES PAR GEM EN TANT QU'INHIBITEURS DE CYCLE CELLULAIRE
Abstract: front page image
(EN)Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
(FR)L'invention porte sur des composés, des compositions pharmaceutiques et des procédés qui sont utiles dans le traitement de troubles à médiation par CDK4, tels que le cancer. Les composés selon l'invention sont des dérivés de pyridine, pyrimidine et triazine disubstitués par GEM ou spirocycliques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)