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1. (WO2009126122) PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE ALTERATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/126122    International Application No.:    PCT/US2008/004580
Publication Date: 15.10.2009 International Filing Date: 10.04.2008
IPC:
C12Q 1/68 (2006.01)
Applicants: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC [US/US]; 1401 Rockville Pike, Suite 600 Rockville, MD 20852 (US) (For All Designated States Except US).
SRIVASTAVA, Shiv [US/US]; (US) (For US Only).
DOBI, Albert [HU/US]; (US) (For US Only).
SREENATH, Taduru [US/US]; (US) (For US Only).
PETROVICS, Gyorgy [US/US]; (US) (For US Only).
SUN, Chen [CN/US]; (US) (For US Only)
Inventors: SRIVASTAVA, Shiv; (US).
DOBI, Albert; (US).
SREENATH, Taduru; (US).
PETROVICS, Gyorgy; (US).
SUN, Chen; (US)
Agent: DONALDSON, Timothy, B.; MH2 Technology Law Group LLP 1951 Kidwell Drive Suite 550 Tysons Corner, VA 22182 (US)
Priority Data:
Title (EN) PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE ALTERATIONS
(FR) ALTÉRATIONS DANS L'EXPRESSION DU GÈNE ERG SPÉCIFIQUES DU CANCER DE LA PROSTATE ET PROCÉDÉS DE DÉPISTAGE ET DE TRAITEMENT BASÉS SUR CES ALTÉRATIONS
Abstract: front page image
(EN)Alterations in ERG gene expression can be observed in patients with prostate cancer. Specific ERG isoforms are associated with, or involved in, prostate cancer. Compositions comprising these isoforms provide therapeutic benefit and can be used in methods of detecting, diagnosing, prognosing, and treating prostate cancer. These compositions provide biomarkers for detecting the expression of combinations of the PSA/KLK3, PMEPA1, NKX3.1, 0DC1, AMD1, and ERG genes.
(FR)Des altérations dans l'expression du gène ERG peuvent être observées chez les patients atteints du cancer de la prostate. Des isoformes ERG spécifiques sont associées à, ou impliquées dans le cancer de la prostate. Des compositions comprenant ces isoformes fournissent un bénéfice thérapeutique et peuvent être utilisées dans des procédés de dépistage, de diagnostic, de pronostic, et de traitement du cancer de la prostate. Ces compositions fournissent des biomarqueurs pour détecter l'expression de combinaisons des gènes PSA/KLK3, PMEPA1, NKX3.1, 0DC1, AMD1, et ERG.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)