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1. (WO2009125870) PYRIMIDINE, PYRIDINE AND TRIAZINE DERIVATIVES AS MAXI-K CHANNEL OPENERS.

Pub. No.:    WO/2009/125870    International Application No.:    PCT/JP2009/057541
Publication Date: Oct 15, 2009 International Filing Date: Apr 8, 2009
IPC: C07D 239/47
C07D 213/64
C07D 239/34
C07D 239/42
C07D 251/30
A61K 31/505
A61K 31/44
A61K 31/53
C07D 401/04
C07D 409/14
C07D 403/04
A61K 31/506
A61K 31/4427
A61P 13/10
A61P 11/06
A61P 9/10
Applicants: MITSUBISHI TANABE PHARMA CORPORATION
TSUZUKI, Yasuyuki
HIRAI, Miki
Inventors: TSUZUKI, Yasuyuki
HIRAI, Miki
Title: PYRIMIDINE, PYRIDINE AND TRIAZINE DERIVATIVES AS MAXI-K CHANNEL OPENERS.
Abstract:
A compound of formula (A); wherein ring A is an aromatic ring or a heteroaromatic ring; R1 is independently halogen, cyano, etc., each of X1, X2 and X3 is CR2 or nitrogen, R2 is independently hydrogen, etc., n is 0, 1, 2, 3 or 4; -D-Y is -O-CH2COOH, etc, and G is a substituted amino, a substituted heterocyclic group, etc, or a pharmaceutical acceptable salt thereof, has activities of opening BK channels.