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1. WO2009124167 - HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS

Publication Number WO/2009/124167
Publication Date 08.10.2009
International Application No. PCT/US2009/039253
International Filing Date 02.04.2009
IPC
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 13/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
CPC
A61K 31/428
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 13/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
06Anti-spasmodics
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US] (AllExceptUS)
  • BERGER, Richard [US]/[US] (UsOnly)
  • CHANG, Lehua [CN]/[US] (UsOnly)
  • EDMONDSON, Scott, D. [US]/[US] (UsOnly)
  • GOBLE, Stephen, D. [US]/[US] (UsOnly)
  • HA, Sookhee, Nicole [US]/[US] (UsOnly)
  • KAR, Nam, Fung [US]/[US] (UsOnly)
  • KOPKA, Ihor, E. [US]/[US] (UsOnly)
  • LI, Bing [US]/[US] (UsOnly)
  • MORRIELLO, Gregori, J. [US]/[US] (UsOnly)
  • MOYES, Chris, R. [GB]/[US] (UsOnly)
  • SHEN, Dong-Ming [US]/[US] (UsOnly)
  • WANG, Liping [US]/[US] (UsOnly)
  • ZHU, Cheng [CN]/[US] (UsOnly)
Inventors
  • BERGER, Richard
  • CHANG, Lehua
  • EDMONDSON, Scott, D.
  • GOBLE, Stephen, D.
  • HA, Sookhee, Nicole
  • KAR, Nam, Fung
  • KOPKA, Ihor, E.
  • LI, Bing
  • MORRIELLO, Gregori, J.
  • MOYES, Chris, R.
  • SHEN, Dong-Ming
  • WANG, Liping
  • ZHU, Cheng
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
61/123,06304.04.2008US
61/206,04327.01.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
(FR) HYDROXYMÉTHYL PYRROLIDINES EN TANT QU’AGONISTES DE RÉCEPTEUR BÊTA 3 ADRÉNERGIQUE
Abstract
(EN) The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
(FR) L’invention concerne des composés de formule (I), leurs compositions pharmaceutiques, et un procédé pour les utiliser dans le traitement ou la prévention de maladies véhiculées par l’activation de l’adrénocepteur b3.
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